DocumentsDate added
Original research article:-
1Padmapriya, B*., 1Leema , M.C.E., 1Anishya , R.S ., 1Dhivya Prabha , R ., 1Tamilarasi.G.
1.Department of Microbiology, School of Life sciences, Karpagam University. Coimbatore.21, TamilNadu, India.
Abstract:-According to World Health Report of Infectious diseases 2000, overcoming antibiotic resistance is the major issue of the WHO for the next millennium. Hence the last decade witnessed an increase in the investigation of plants as a source of human disease management. The aim of the present study was to investigate antibacterial activity of the various extracts of Hibiscus sabdariffa and Solanum trilobatum. The powdered plant leaves materials were extracted in n-hexane, chloroform, ethyl acetate, ethanol and water and their antibacterial activities were examined against some collected clinical isolates using agar dilution method. The qualitative screening of phytochemical compounds of H. sabdariffa and S.trilobatum were performed. Ethanolic extract of Hibiscus sabdariffa and hexane extract of Solanum trilobatum gave the highest inhibition against all the urinary isolates. The presence of starch, proteins, aminoacids, steroids, cardiac glycosides, saponin glycosides, coumarin glycosides, flavanoids, tannins ,phenolic compounds and the presence of steroids, cardiac glycosides and coumarin glycosides, aminoacids and flavanoids were observed in the phytochemical screening of H. sabdariffa and S. trilobatum extracts respectively. These findings reveals that antimicrobial activity especially against the urinary pathogens of the selected plant extracts may be due to the presence of these phytochemicals. The spectra of activities displayed by the extract signifies the potency of Hibiscus sabdariffa and Solanum trilobatum as a source of therapeutic agents and may provide leads in the on going search for antimicrobial agent from plants.
Keywords: Antimicrobial, Ethanolic extract, Hibiscus sabdariffa, phytocemical properties, Solanum trilobatum, Uropathogens.
Review article:-
Puratchikody A 1, *Swarnalatha S 2
1.Department of Pharmaceutical Technology, AnnaUniversity, Tiruchirappalli – 620 024, India.
2.K.R.S Pallavan College of Pharmacy, Thandalam, Chennai – 602 105, India .
Abstract:-Many herbal remedies have been employed in various medicinal systems for the treatment and management of different diseases .The Indigofera Asplathoides commonly known as “Sivanar Vembu” has been recognized in different system of traditional medicines for the treatment of different diseases and ailments of human beings. This review supports all updated information on its pharmacognosy, pharmacological activity and traditional uses. Preliminary phytochemical screening of this plant revealed the presence of tannins, flavonoids, alkaloids, glycoside, and steroids. It has been reported as anticancer, antimicrobial, hepatoprotective, hypoglycemic, antioxidant, antibacterial, antiviral, anti-inflammatory, antineoplastic activity. The leaves, flowers and tender shoots of the plant were said to be cooling and demulcent and are employed as a decoction in leprosy and cancerous infections. There is no report available on isolated constituents of bioactive compound from whole plants Indigofera Aspalathoides which support its further to isolating a useful pharmacologically active compound as a drug.
Key words:- Indigofera Aspalathoides, Sivanar vembu, Pharmacognostical, Pharmacological, Traditional uses.
Original research article:-
1Siddiqui Aslam Iqbal*,M.Pharm(Pharmaceutics),1Bakde Bharti Vidya,M.Pharm (Pharmaceutic), 3Dr. Kiran K Tappar (Ph.D.)
1.Pataldhamal Wadhwani College of pharmacy, SGB Amravati University, Yavatmal-445001, Maharashtra, India.
2.Vidya Bharati College of pharmacy, Amravati, Maharashtra, India.
Abstract:-The present research work aimed to design a gastro retentive floating drug delivery system for sustained release of Diltiazem Hydrochloride. Diltiazem HCl has site specific drug absorption from upper part of gastrointestinal tract and it is insoluble at higher pH (i.e. lower part of GI tract), therefore poorly absorbed from lower part of GI tract. Unabsorbed drug causes impaired therapeutic effect, increases frequency of dose administration and contributes to more side effects. Therefore a gastro retentive dosage form is required to ensure the controlled drug delivery of Diltiazem HCl within a drug absorbable region. Various grades of low density polymers (HPMC K4M, HPMC K15M, HPMC K100M and Xanthan gum) were used for formulation of this system. They were prepared by physical blending of Diltiazem HCl, polymers and effervescent agent in varying ratios. The formulation was optimized on the basis of In vitro bouncy and In vitro release in 0.1 N HCL buffer solutions. In vitro buoyancy was found to be in the range of 10 to 25 seconds and percent swelling index in the range of 130 to 332 %. Floating time was more than 12 hrs. In vitro drug release of the optimized batch (F5) was found to be 94.15 % at the end of 12th hr and it show the best fit model as matrix and it shows non-fickian type of drug release. The floating tablets were also evaluated for uniformity of weight, hardness, friability, drug content and effect of hardness on floating lag time.
Keywords: Effect of Hardness on Floating Lag Time and Total, Floating time, In vitro, Buoyancy studies, Mechanism of release, Water uptake study.
Review article:-
*VijayKumar Chauhan1, Dr. Rajesh K.S1, Deepak.G.Umalkar1, Lokendra Pal Singh1, Khushbu Shah1, Kuldipsinh Pagi1.
1.Department of Pharmaceutics, Parul Institute of Pharmacy, Limda, Vadodara, Gujarat-391760, India.
Abstract:-Now day’s formulation research is breaking barriers of conventional methods. Today, active ingredients can be delivered with a level of convenience, performance and bioavailability never seen in the market place. Fast disintegrating or Mouth dissolving tablet (MDTs) is one such novel approach to increase consumer acceptance by virtue of rapid disintegration, self administration without water or chewing. This novel type of delivery system offers convenience for treatment-resistant population who have difficulty in swallowing unit oral dosage form, namely Tablets and Capsules. These formulations are particularly beneficial to pediatric and geriatric patients. It is estimated that 50 % of the population is affected by dysphagia which results in high incidence of non-compliance and ineffective therapy. The aim of this article is to review the ideal properties, significance, characteristics, limitation, choice of drug candidates, challenges in formulation, approaches for preparation of MDTs, Patented technologies on MDTs, Suitable drug candidates for MDTs, Marketed product of MDTs, and Evaluation tests of MDTs.
Key words: Fast disintegrating, Mouth Dissolving Tablet, Dysphagia.
Original research article:-
Goel Chirag, Verma Pankaj, Ahmad Naseer, Nailwal K Tapan* Department of Biotechnology, Kumaun University, Nainital, Campus, Bhimtal - 263136, Uttarakhand, India.
Abstract:-Urtica parviflora is considered as an important Medicinal plant, due to its various ethanomedical uses. Here, we analyze the Genetic Variation in U.parviflora, with respect to plant distribution in Kumaun hills based on change in altitude. Examination of Random amplified Polymorphic DNA (RAPD) markers from four plant samples collected at different heights from sea level indicated that genetic variation was appreciable, as samples from lower altitudes showed low genetic similarity with samples collected from higher altitudes. A total of 70 scorable bands were produced in four samples with 8 primers. The average number of bands per primer was 8.75. Out of 70 bands, 48 bands were polymorphic (68.75%) noted in the present investigation. The dendrogram of the samples showed two major clusters. The samples of Mukteshwar, Nainital and Bhowali are in one cluster and Bhimtal in other cluster.
Key words: Genetic Diversity, Primers, RAPD analysis, Taq DNA polymerase.