DocumentsDate added
Review article:- *Gunjan Mahendru1, P. K. Sharma1, V. K. Garg1, A. K. Singh1, S. C. Mondal
1. Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology, Baghpat Bypass, NH-58, Meerut-250005, Uttar Pradesh, India.
Abstract:- Dengue has become a major health problem in India. It is mainly transmitted to humans by Aedes aegypti mosquito, which constitutes the etiological agents of the disease. So, for treating this disease goat milk and milk products are mostly preferred. Selenium (Se) is the main component of goat milk. Deficiency of Selenium and decrease in platelet count are the main complications of dengue fever. Goat milk as well as milk products are richest source of Selenium (Se) as comparison to cow and sheep milk. Goat milk also found to help with the digestive and metabolic utilization of various minerals.
Keywords:-Dengue fever, Goat Milk, Milk Products, Selenium, Platelet Count.
Original research article:- 1N. Rathankar*, 2Kuldeep. D. Raju, , and 3H. G. Nagendra
1.Asst. Professor, Department of Bioinformatics, School of Bioengineering, SRM University, Kattankulathur, Tamilnadu, India.
2.Associate clinical data coordinator, Quintiles, Bangalore 560 001,India.
3.Professor and Head, Department of Biotechnology, Sir M. Visvesvaraya Institute of Technology, Near Hunasamaranahalli, Via Yelahanka, Bangalore 560 001,India.
Abstract:- Low Complexity regions (LCRs) in proteins are sequences containing regular repeats, cryptic repeats and single amino acid repetitions, recognized by their compositional bias , Some of these regions are highly conserved between species in both composition and sequence. These low complexity sequences are simple sequences and contain sequence segments that are entropically low. Some of these sequences do not contain a structurally homolog and are considered as information less. The SEG program originally designed by Wootton and Federhen (1993) was the first program to predict these LCRs in protein sequences. For nearly a decade, this program was used by various database search tools such as NCBI-Blastp , megablast , etc to avoid spurious hits during sequence searches by masking the low complexity regions and it is really unfortunate to note that, such fragments did not receive wide attention for a long time despite its crucial role in diseases . In this paper, an attempt to mark the importance of LCRs in drug targets related to cancer has been catalogued by us. Key Words:-Low complexity regions, SEG, cancer targets, simple sequences, polyglutamine runs.
Review article:- *Huma Noor1, P. K. Sharma1, V. K. Garg, A. K. Singh1, S. C. Mondal1
1.Meerut Institute of Engineering and Technology, Baghpat Bypass, NH-58, Meerut-250005, Uttar Pradesh, India.
Abstract:- Hypoglycemia, a condition characterized by low blood sugar, is the most feared complication and a fact of life for those patients which are suffering from diabetes mellitus. Hypoglycemia may occur due to a variety of circumstances such as decrease calorie intake due to illness or hospital routine but usually it is iatrogenic. It is mainly responsible for recurrent morbidities in most of the diabetic patients and act as a barrier to maintain euglycemia for the lifetime. Typically it is the result of absolute or relative insulin excess as well as compromised glucose counterregulation in diabetes which provides the ground for long term morbidities like hypoglycemia unawareness; hypoglycemia associated autonomic failure (HAAF), counterregulatory hormonal deficiencies and in rare cases permanent impairment of cognitive functions. The frequency of hypoglycemic episodes further increase when these clinical syndromes segregate together and a vicious cycle of hypoglycemia start. Hypoglycemia may develop in both type of diabetes mellitus but patients having type 2 diabetes are at low risk in comparison to those suffering from type 1 diabetes. Some counterregulatory factors which are important for prevention of hypoglycemia are glucagon, epinephrine, cortisol, growth hormone. It has been observed that glucose counterregulatory mechanism generally remains intact in patients having type 2 diabetes, although it can be more dangerous because they are generally older and may have co morbidities. In this review article, we focus on frequencies of episodes, clinical manifestations, possible pathophysiological mechanisms related with hypoglycemia and also discuss about hypoglycemia associated risk factors, treatment and preventive strategies.
Keywords:- Hypoglycemia, Iatrogenic, Euglycemia, Glucose counterregulation, Hypoglycemia unawareness, Hypoglycemia associated autonomic failure.
Original research article:-* Kavita G.U1, Shashikala P2, Manjula. A 3, Vijayanath.V4 , Anitha.M.R5
1.Associate Professor, Department of Pathology,S.S.Institute of Medical Sciences & Research Centre ,Davangere, Karnataka,India.
2.Professor and Head, Department of Pathology, S.S.Institute of Medical Sciences & Research Centre, Davangere, Karnataka,India.
3.Assistant Professor, Department of Pathology,S.S.Institute of Medical Sciences & Research Centre ,Davangere, Karnataka,India.
4.Associate Professor,Department of Forensic Medicine & Toxicology,S.S.Institute of Medical Sciences & Research Centre,Davangere, Karnataka,India.
5.Assistant Professor,Department of Anatomy, S.S.Institute of Medical Sciences & Research Centre,Davangere, Karnataka,India.
Abstract:- Anal tumors are rare and are 20-30 times less common than colonic cancers. Tumors of the anus occur throughout the world but are particularly common in Brazil and India. The present study was undertaken to know the histomorphological patterns and incidence of anal cancers in and around Davangere, a district in central Karnataka. Anal cancers constituted 0.17% of the total specimen received for histopathology. Females (72.22%) were more commonly affected than males(27.77%). Squamous cell carcinoma was the commonest histomorphologic type of malignancy.(50%).Since symptoms of anal cancer are mostly attributed to benign conditions by most patients as well as doctors, proper identification, diagnosis and typing of the anal cancers is necessary for appropriate treatment of the same.
Key Words:- Carcinoma, cancer.
Review article:- *Goyal Parveen Kumar1(M.Pharm.,PGDPL), Sharma Shekhar2 (M.Pharm, DIPL), Kumar Rishi3 (M.Pharm.)
1.Department of Pharmacology, Hindu College of Pharmacy, Sonepat-131001, Haryana ,India.
2.Department of Pharmaceutical Biotechnology, Hindu College of Pharmacy, Sonepat-131001, Haryana ,India.
3.Department of Pharmacognosy, IIMT College of Pharmacy, Greater Noida, India-201306.
Abstract:- The prescription drugs are generally either branded/innovator or generic drugs. The process of drug discovery and development, including FDA approval and clinical trials, is quite expensive and consumes many years to bring any innovator drug in market thereby branded drugs are of fairly high cost which are beyond the reach of general public. To achieve the goal of health care system, promotion and preservation of health at the level of general public, only branded drugs are not sufficient hence generic drugs, that contain same active ingredients, as of innovator drug, comparable in terms of strength, quality and therapeutic effectiveness, sold at low cost, are required. The Hatch Waxman Act support generic companies, procure generic drugs to common people at reasonable price, and also maintained the balance between innovator and generics. This manuscript describes how Hatch-Waxman Act provide the generics at lower cost in the reach of general public as well as rejuvenate the drying pipeline of patented drugs.
Keywords: Hatch Waxman, Generic, Innovator, Exclusivity, ANDA, Paragraph IV Certification.