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Review article:- *Gunjan Mahendru1, P. K. Sharma1, V. K. Garg1, A. K. Singh1, S. C. Mondal
1. Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology, Baghpat Bypass, NH-58, Meerut-250005, Uttar Pradesh, India.
Abstract:- Dengue has become a major health problem in India. It is mainly transmitted to humans by Aedes aegypti mosquito, which constitutes the etiological agents of the disease. So, for treating this disease goat milk and milk products are mostly preferred. Selenium (Se) is the main component of goat milk. Deficiency of Selenium and decrease in platelet count are the main complications of dengue fever. Goat milk as well as milk products are richest source of Selenium (Se) as comparison to cow and sheep milk. Goat milk also found to help with the digestive and metabolic utilization of various minerals.
Keywords:-Dengue fever, Goat Milk, Milk Products, Selenium, Platelet Count.
*Soumendra Sahoo 1, Rashmirekha Sahoo 2, , and Padma Lochan. Nayak 3 .
1.Associate Professor, Ophthalmology, Melaka Manipal Medical College,Malaysia.
2Senior Lecturer, Faculty of Science & Technology, Nilai University College, Nilai, Malaysia. 3.P.L.Nayak,Chairman PL Nayak Research Foundation & Institute of Nanobiotechnology, Neelachal Bhavan, Bidyadharpur, Cuttack- 753004, Odisha, India.
Abstract:- Polysaccharide based biomaterials are an emerging class in several biomedical fields such as tissue regeneration, particularly for cartilage, drug delivery devices and gel entrapment systems for the immobilization of cells. Important properties of the polysaccharides include controllable biological activity, biodegradability, and their ability to form hydrogels. Most of the polysaccharides used derived from natural sources; particularly, tamarind seed polysaccharide (TSP), alginate and chitin, three polysaccharides which have an extensive history of use in medicine, pharmacy and basic sciences, and can be easily extracted from tamarind kernel powder, marine plants (algae kelp) and crab shells, respectively. The recent rediscovery of poly-saccharide based materials is also attributable to new synthetic routes for their chemical modification, with the aim of promoting new biological activities and/or to modify the final properties of the biomaterials for specific purposes. These synthetic strategies also involve the combination of polysaccharides with other polymers.
Key words:- Polysaccharides; TSP, Ocular, Mucoadhesive, Drug Delivery.
Original Research article:-
*Jadhav Ravindra T1, Patil Pratibha R.2, Patil Payal H2
1.M.J.Biopharm Pvt. Ltd., L-7, M.I.D.C. indl. Area, Taloja, Raigad District, Maharashtra., India. 2.Department of Quality Assurance & Pharmaceutics,R.C.Patel Institute of Pharmaceutical Education & Research,Shirpur- 425405, Dhule District, Maharashtra., India.
Abstract:-The aim of present work was to develop a semisolid preparation (ointment, gel, cream) of Thiocolchicoside which is a cen-trally acting skeletal muscle relaxant for the effective treatment of muscle spasm. Thiocolchicoside has been claimed to posses GABA mimetic & glycinergic actions in other way can say that Thiocolchicoside is a gama-aminobutyric receptor agonist. It has recently been shown that thiocolchiocoside activity can be ascribed to its ability of interacting with strychnine sensitive glycine receptors & therefore that compounds endowed with the glycino-mimetic activity can be used in rheumatologic-orthopedic field for their muscle relaxant properties. It is widely prescribed for treatment of muscle spasm, cramps, musculoskeletal & neuromuscular disorder. Thiocolchicoside is available in market in the form of capsules & Injection. The major problem associated with Thiocolchicoside is its bioavailability which is very low i.e. 25% only so in order to minimize drug loss due to first pass metabolism, and overcome problem associated with low bioavailability drug there is need to formulate semisolid preparation . The aim of the study was to formulate & evaluate thiocolchicoside ointment, gel & cream and comparative study of their drug release. In vitro release of thiocolchicoside from the three bases i.e., ointment, gel, cream to an aqueous receptor phase through whatman filter paper no.41 as well as mice skin was monitored spectrophotometrically at a wavelength of 259nm. In vitro release study results showed that the steady state fluxes of the drug from vehicles rank according to the following order: ointment >gel >cream. Ointment base showed considerably higher drug release than other vehicles.
Key words :- Thiocolchicoside, ointment, gel, cream, diffusion.
Original research article:- Abdul Bari Mohd1, P.Swathimutyam1, A.Padmanabha Rao1, *Nalini Shastri2, and Prakash V Diwan1
1.Department of Pharmaceutics, School of Pharmacy (formerly Lalitha College of Pharmacy),Venkatapur, Ghatkesar,Hyderabad, AP ,India.
2.Department of Pharmaceutics, NIPER, Hyderabad, AP , India.
Abstract:-The present study was designed to develop a newer method for nano emulsions with glibenclamide as a anti diabetic drug. The method was carried out using (Gemini5µ C18 110A 100×4.60mm 5micron) with mobile phase comprised of methanol: 0.2M phosphate buffer PH 7.0 in the ratio (70:30). The flow rate at 1.0 ml/min and effluent was detected at 228nm. The retention time of glibenclamide was observed at 3.2 minutes. The method was validated for specificity, accuracy, precision, linearity, and limit of detection, limit of quantification, robustness and solubility. LOD and LOQ were 200 and 800 ng/ml respectively. The calibration curve was linear in the concentration range of 1- 2 µg/ml with coefficient correlation of 0.999. The percentage recovery for the glibenclamide was 99.8% and % RSD was less than 1 %. There are scanty reports with relation to determination of gliblencamide in nanoemulsion formulation. The proposed method was used for quantitative determination of glibenclamide in nano emulsion and is authenticated using various parameters.
Key words:- Glibenclamide, Anti diabetic drug, methanol, phosphate buffer, HPLC, Validation.
Review article:- *Raju S1, Kavimani S 2, Uma Maheshwara rao V3, Sreeramulu Reddy K4
1.Assistant Professor, Vijaya College of Pharmacy, Munaganoor, Ranga Reddy Dist, Andhra Pradesh, India-505511.
2.Mother Theresa Post Graduate Institute of Health Sciences, Gorimedu, Puducherry, India.
3.Nalla Narsimha Reddy College of Pharmacy, Korremula, Ranga Reddy Dist, Andhra Pradesh.
4.Assistant manager –Clinical R&D, Shantha Biotechnics Limited, Hyderabad, Andhra Pradesh. India- 500004.
Abstract:- Many herbal remedies have so far been employed for the treatment and management of various ailments since the beginning of human civilization. Tecoma stans Juss. (Bignoniaceae) is a plant widely distributed in Mexico and frequently used for the treatment of Diabetes mellitus symptomatology. The aim of this review was to collect all available scientific literature published and combine it into this review. The present review comprises the ethnopharmacological, phytochemical and therapeutic potential of Tecoma stans. The present review includes 43 references compiled from major databases as Chemical Abstracts, Science Direct, SciFinder, PubMed, Dr. Dukes Phytochemical and Ethnobotany. An exhaustive survey of literature revealed that alkaloids, flavonoids, saponins, phenols, steroids, anthraquinones and tannins, terpenes, phytosterols and glycosides constitute major classes of phytoconstituents of this plant. Pharmacological reports revealed that it is having antidiabetic, anticancer, antioxidant, antispasmodic, antimicrobial, and antifungal, properties, and extensively used in the treatment of diabetes. Tecoma stans seems to hold great potential for in-depth investigation for various biological activities, Through this review, the authors hope to attract the attention of natural product researchers throughout the world to focus on the unexplored potential of Tecoma stans, and it may be useful in developing new formulations with more therapeutic value.
Key Words:- Ethnobotany, Phytochemistry, Pharmacology, Antidiabetic, Tecoma.