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Research article:- * Majumdar T , Debbarma N, Roy D B.
*Assistant Professor, Department of Microbiology, Agartala Government Medical College Agartala,Tripura ,India.
Abstract:- Objectives- This study was undertaken to evaluate the therapeutic efficacy of Chloroquine in uncomplicated P. falciparum malaria and to observe the pattern of drug resistance in a known Malaria endemic area in Dhalai District of Tripura, as per guidelines adopted by National Vector Borne Disease Control Programme (NVBDCP) in order to propose second line treatment in effected area. Methods-Study design was as per modified protocol for In vivo study of CQ resistance as adopted by NVBDCP. Active survey of fever cases were carried out in one Gaon Panchayet and four sub centers under Kulai Rural Health Centre of Dhalai District of Tripura, along with blood slide collection of both thick & thin film. Chloroquine administered as per body weight in P. falciparum positive cases and cases were followed up for 28 days for clinical as well as parasitological response. Results-Out of 300 slides examined 98 (32.7%) are found to be positive for malaria. Out of which Plasmodium falciparum ( Pf) ring in 78(79.6%), Pf gametocytes- 5(5.1%),Plasmodium vivax( Pv) - 10 (10.2%),Pf+Pv-5(5.1%). Total 53 cases were included in the study, out of which 40 no. of cases had complete follow up for 28 days .Early Treatment Failure (ETF) was detected in 13(32.5%) cases, Late Clinical & Parasitological Failure (LCF) was 14(35%), Adequate Clinical & Parasitological Response(ACPR) was 13(32.5%).Conclusion- Chloroquine resistant found to be 67.5%( 27/40) . Based on this study Dhalai District was declared as Drug Resistant to Chloroquine as per drug policy of NVBDCP and oral Artisunate and Sulphadoxine + Pyremethamine (ACT) combination therapy was advocated.
Keywords:- Plasmodium, Chloroquine resistance, Tripura, ETF, LCF, ACPR.
Research article:-
R. Ramya, S. Prakash, S. Sudha*
Molecular Diagnosis and Drug Discovery Laboratory, Department of Biotechnology, School of Life Sciences, Karpagam University, Coimbatore, Tamilnadu, India.
Abstract:-Context: Oral squamous cell carcinoma (OSCC) is one of the most common malignant tumors. Its incidence is rated as one among the highest in the world and the use of tobacco in various forms is increasingly associated with the cause of OSCC. Tobacco contains many carcinogenic and mutagenic chemicals which induce the generation of free radicals and reactive oxygen species (ROS) with increased level of lipid peroxidation. Malondialdehyde (MDA) is a major lipid peroxidation product that is mutagenic and tumorigenic. Aim: To investigate the relationship between serum levels of malondialdehyde (MDA), a routinely used marker of oxidative stress, and squamous cell carcinoma of the oral cavity. Methods: Serum malondialdehyde (MDA) levels in 40 histologically proven OSCC cases and 40 age matched controls were analyzed. Results and conclusion: Serum MDA levels in cancer patients were significantly higher than those in controls (P < 0.05). There was a significant association between increased MDA levels and tobacco habits. The results of this study provide further evidence that there is relationship between serum MDA and OSCC. The study hypothesizes that oxidant/antioxidant imbalance may be one of the major factor responsible for the development of oral cancer.
Key words:- Oral squamous cell carcinoma, Malondialdehyde, Lipid peroxidation.
Case Report:- *Dr Vandana Berry1,Mr Vidya Sagar1,Dr Madan Lal1 and Dr Amarjit Singh Vij2
1.Dept of Microbiology, Christian Medical College & Hospital , Ludhiana, Punjab,India. 2.Dept of Medicine, Punjab Institute of Medical Sciences , Jalandhar, Punjab, India.
Abstract:- Aspergillus is frequently associated with varied systemic infections in immnocompromised hosts. Such infections are quite hard to treat after the involvement of various vital organs. Many cases of generalized Aspergillosis in AIDS patients have been reported. Here we report a case of septicemia by Aspergillus flavus in a diabetic female in whom meningitis with acute renal failure developed leading to the death of the patient.
Key words:- Aspergillus flavus, Septicaemia, Meningitis, Acute Renal Failure, Sabouraud’s Dextrose Agar.