DocumentsDate added
Research article:- *Ashish Jain1, Satish Nayak2, Vandana Soni3 *
1 M.Pharm, Assistant Professor, Bansal College of Pharmacy, Kokta, Anand Nagar, Bhopal-462021, India.
2.Ph.D., Director, Bansal College of Pharmacy, Kokta, Anand Nagar, Bhopal-462021, India.
3.Ph.D., Professor, Department of Pharmaceutical Sciences, Dr H.S.Gour Vishwavidyalaya, Sagar 470003, M.P. India.
Abstract:- The pupose of the present work was to assess iontophoretic transdermal delivery of Captopril across pigskin for its transdermal development. In vitro iontophoretic transdermal delivery of Captopril across the pigskin was investigated at three different drug concentrations and tree different current densities (0.25- 075 mA/cm2 ) in the donor cell of the diffusion apparatus, using cathodal iontophoresis along with the passive controls. For passive permeation, the steady state flux significantly increased with the donor drug concentration. At all concentration levels, iontophoresis considerably increased the permeation rate compared to passive controls. Iontophoretic transport of Captopril was to be found with current densities. Flux enhancement was highest at the lowest drug load and lowest at the highest drug load. We concluded permeation rate of drugs across the pigskin can be considerably enhanced by the use of Iontophoresis.
Keywords: Captopril; Iontophoresis; Pigskin; Transdermal drug delivery.
Research article:- *Amit Pandey1, Rajesh Kumar2
1.R&D Division, MRD LifeSciences, Lucknow-226010, India.
2.Institute of Biosciences & Biotechnology, CSJM University, Kanpur -802024, India.
Abstract :-The antibacterial properties of “Lawsonia inermis” commonly known as “Henna or Mehandi” tested against bacterial pathogens (S. aureus, P. aeruginosa and E. coli). Agar diffusion susceptibility test revealed inhibition zone of Henna sample. The Henna leaves were exhibiting best result followed by fruits, bark root and stems. The solvents were used ethanol, methanol, ethyl acetate and hot water, compare to all, ethanolic extract and ethyl acetate extract were showing best result against one gram positive culture Staphylococcus aureus (MTCC 2940) and two gram negative cultures Pseudomonas aeruginosa (MTCC 2453) and E. coli (MTCC 739). The MIC value was determined by using broth dilution methods. Ethanolic extract of Henna was subjected to get the MIC against test organisms and it was found to be 1.45 mg/ml for E. coli and Pseudomonas aeruginosa.
Keywords:- Antibacterial properties, ethanolic and ethyl acetate plant extract, MIC, zone of inhibition.