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Review article:- *Srujan Reddy1, Palash Das1, Harika Das1, Arpita Ghosh2.
*1Department of Pharmaceutics, SRM University, Chennai, India.
1Department of Pharmaceutics, MLR Institute of Pharmacy, Dundigal, Hyderabad, India.
2Department of Pharmaceutics, Bojjam Narsimhulu College for Women, Hyderabad , India.
Abstract:-Compaction of multiparticulates, commonly called MUPS, is one of the more recent and challenging technologies that combine the advantages of both tablets and pellet-filled capsules in one dosage form. This article reviews the advantages and drawbacks of MUPS, properties of an ideal MUPS dosage form, mechanisms involved in their compaction, their disintegration and dissolution behavior, objectives/rationale involved in the design of MUPS dosage form, challenges in their compaction and key variables to be considered in successful production of MUPS.
Key words:- MUPS, multiparticulates, pellets, tablets, compaction, compression, tabletting.
Research article:- *Kunal Madhav1, Satish Verma2, Ritu Tanta3 .
1Lecturer, Department of Microbiology, Sai Institute of Paramedical And Allied Sciences, Dehradun, Uttarakhand, India.
2Lecturer, Department of Biotechnology, Sai Institute of Paramedical And Allied Sciences, Uttarakhand ,India.
3Department of Microbiology , Sai Institute of Paramedical And Allied Sciences, Dehradun, Uttarakhand, India.
Abstract:- The present work is focused on the isolation of Bacillus spp. from the soil sample of industrial, city and agricultural land in Dehradun (Uttarakhand). The collected samples were labeled as Agricultural soil sample (ASB), Industrial soil sample (ISB) and city soil sample (CSB). Soil samples were then serially diluted in normal saline and plated on sterile nutrient agar plates. The colonies obtained from higher dilutions were subjected to Gram staining, biochemical reactions and starch hydrolysis test. Bacterial colony yielding positive starch hydrolysis test were subjected to Amylase activity test. The amylase activity was also carried on the isolated bacteria with respect to time, temperature and pH of the media in which it was inoculated. The result showed that the maximum amylase activity in case of Agricultural soil (34.2%) followed by city sample (26.07%) and industrial sample (21.79%). Amylase activity was also checked with respect to temperature, time and pH. The activity of amylase was seen to increase with respect to time, pH and temperature which was found to be 18.33 IU, 6.89 IU and 6.85 IU in case of Agricultural soil bacilli respectively; whereas both city and industrial soil sample yielded comparatively low results.
Keywords:- Amylase activity, Bacilli, Soil, pH effect.
Research article:- * Vidyadhar B. Bangal1, Purushottam A. Giri2, Bhushan M. Sali3.
1Professor and Head, Dept. of Obstetrics and Gynaecology (OBGY), Rural Medical College & Pravara Rural Hospital of Pravara Institute of Medical Sciences (Deemed University), Loni, Dist. Ahmednagar, Maharashtra, India.
2Assistant Professor, Dept. of Community Medicine (PSM), Rural Medical College & Pravara Rural Hospital of Pravara Institute of Medical Sciences (Deemed University), Loni Dist. Ahmednagar, Maharashtra, India.
3Postgraduate student, Dept. of Obstetrics and Gynaecology (OBGY), Rural Medical College & Pravara Rural Hospital of Pravara Institute of Medical Sciences (Deemed University), Loni Dist. Ahmednagar, Maharashtra, India.
Abstract:- Oligohydramnios or reduced amount of amniotic fluid volume is a commonly observed obstetric problem during third trimester of pregnancy. It accompanies a broad range of reproductive disorders including anomalies of fetus and functional disorders of mother, fetus and placenta. Reduced amniotic fluid volume is associated with adverse perinatal outcome. A prospective hospital based study of total 100 cases of oligohydramnios coming for delivery to Pravara Rural Hospital, Loni was undertaken over a period of two years from October 2007 to September 2009. The information regarding bio-social characteristics, maternal and perinatal outcome were collected and results were analyzed by using percentage and proportion. In the present study, the majority of the cases( 78%) were unbooked and belonged to the age group of 20-30 years and had associated maternal or fetal complications. Postdated pregnancy, pregnancy induced hypertension and fetal congenital anomalies were the commonest complications associated with oligohydramnios. Forty four percent cases were delivered by caesarean section. Overall perinatal mortality was 24%. Cases with severe oligohydramnios and anhydramnios were associated with intrapartum fetal heart rate abnormalities, (16%) low Apgar score and (8%) meconium aspiration syndrome. Every case of oligohydramnios needs careful evaluation, parental counseling and individualized decision regarding timing and mode of delivery. Continuous intrapartum fetal monitoring and good neonatal care support is essential for optimum perinatal outcome.
Keywords:- Maternal outcome, perinatal outcome, Oligohydramnios.
Research article:- *Nagoba Shivappa N.1 , Purushotham Rao K.2, Zakaullah S.3 .
1Karpagam University, Coimbatore (T.N.) India.
2H.K.E.’s College of Pharmacy, Gulbarga (Karnataka) India.
3Al-Badar Rural Dental College & Hospital, Gulbarga (Karnataka) India.
Abstract:- The present investigation aims to design, prepare and evaluate the medicated candy based tablet lozenges of Clotrimazole for paediatric, geriatric and Dysphagic patients and to investigate the suitability of Isomalt and/or liquid glucose as the sugar substitute in the prepared lozenges. The candy based lozenges were prepared by heating and congealing method in a candy based industry on request with sugar base, Acacia, citric acid artificial flavours and colours and other essential excipients. The prepared medicated lozenges were characterized for drug content uniformity, hardness, thickness, weight variation, friability, moisture content, in vitro disintegration and dissolution by pharmaceutical standard methods. Accelerated stability study conducted as per ICH guidelines (zone IV) at 45°C and 75% relative humidity over a period of seven weeks found that there wasn’t any substantial interaction between the drugs, flavor and color and the prepared formulations were stable.
Keywords:- Clotrimazole, lozenges, oral thrush.
Research article:-*Swapna Velivela 1, Sashmitha Samuel.B1, V. Asha Ranjani1, P.Muthuprasanna2.
1MLR Institute of Pharmacy, Dundigal (V), Quthbullapur (M), Hyderabad-43, Andhra Pradesh, India.
2.Hindu college of Pharmacy, Guntur-522002, A.P , India.
Abstract:-Trimetazidine (TMZ) is an effective and well tolerated anti-anginal drug that possesses protective properties against ischemia- induced heart injury. However it has a short coming of a shorter half-life. Hence, in the present investigation extended release pellets of Trimetazidine hydrochloride (TMZ) were prepared using ethyl cellulose polymers to achieve a prolonged therapeutic action by continuously releasing medication over an extended period of time after administration of a single dose. The sustained release formulations were optimized by employing suspension / solution layering technique. The drug release characteristics of all the formulations were evaluated by HPLC technique and stability studies were carried out for about three months at different temperature and humidity conditions.
Key words:- Ethyl cellulose (EC), Sustained release (SR), Trimetazidine (TMZ)