DocumentsDate added
Review article:- *Srujan Reddy1, Palash Das1, Harika Das1, Arpita Ghosh2.
*1Department of Pharmaceutics, SRM University, Chennai, India.
1Department of Pharmaceutics, MLR Institute of Pharmacy, Dundigal, Hyderabad, India.
2Department of Pharmaceutics, Bojjam Narsimhulu College for Women, Hyderabad , India.
Abstract:-Compaction of multiparticulates, commonly called MUPS, is one of the more recent and challenging technologies that combine the advantages of both tablets and pellet-filled capsules in one dosage form. This article reviews the advantages and drawbacks of MUPS, properties of an ideal MUPS dosage form, mechanisms involved in their compaction, their disintegration and dissolution behavior, objectives/rationale involved in the design of MUPS dosage form, challenges in their compaction and key variables to be considered in successful production of MUPS.
Key words:- MUPS, multiparticulates, pellets, tablets, compaction, compression, tabletting.
Research article:- * Vidyadhar B. Bangal1, Purushottam A. Giri2, Bhushan M. Sali3.
1Professor and Head, Dept. of Obstetrics and Gynaecology (OBGY), Rural Medical College & Pravara Rural Hospital of Pravara Institute of Medical Sciences (Deemed University), Loni, Dist. Ahmednagar, Maharashtra, India.
2Assistant Professor, Dept. of Community Medicine (PSM), Rural Medical College & Pravara Rural Hospital of Pravara Institute of Medical Sciences (Deemed University), Loni Dist. Ahmednagar, Maharashtra, India.
3Postgraduate student, Dept. of Obstetrics and Gynaecology (OBGY), Rural Medical College & Pravara Rural Hospital of Pravara Institute of Medical Sciences (Deemed University), Loni Dist. Ahmednagar, Maharashtra, India.
Abstract:- Oligohydramnios or reduced amount of amniotic fluid volume is a commonly observed obstetric problem during third trimester of pregnancy. It accompanies a broad range of reproductive disorders including anomalies of fetus and functional disorders of mother, fetus and placenta. Reduced amniotic fluid volume is associated with adverse perinatal outcome. A prospective hospital based study of total 100 cases of oligohydramnios coming for delivery to Pravara Rural Hospital, Loni was undertaken over a period of two years from October 2007 to September 2009. The information regarding bio-social characteristics, maternal and perinatal outcome were collected and results were analyzed by using percentage and proportion. In the present study, the majority of the cases( 78%) were unbooked and belonged to the age group of 20-30 years and had associated maternal or fetal complications. Postdated pregnancy, pregnancy induced hypertension and fetal congenital anomalies were the commonest complications associated with oligohydramnios. Forty four percent cases were delivered by caesarean section. Overall perinatal mortality was 24%. Cases with severe oligohydramnios and anhydramnios were associated with intrapartum fetal heart rate abnormalities, (16%) low Apgar score and (8%) meconium aspiration syndrome. Every case of oligohydramnios needs careful evaluation, parental counseling and individualized decision regarding timing and mode of delivery. Continuous intrapartum fetal monitoring and good neonatal care support is essential for optimum perinatal outcome.
Keywords:- Maternal outcome, perinatal outcome, Oligohydramnios.
Research article:- *Nagoba Shivappa N.1 , Purushotham Rao K.2, Zakaullah S.3 .
1Karpagam University, Coimbatore (T.N.) India.
2H.K.E.’s College of Pharmacy, Gulbarga (Karnataka) India.
3Al-Badar Rural Dental College & Hospital, Gulbarga (Karnataka) India.
Abstract:- The present investigation aims to design, prepare and evaluate the medicated candy based tablet lozenges of Clotrimazole for paediatric, geriatric and Dysphagic patients and to investigate the suitability of Isomalt and/or liquid glucose as the sugar substitute in the prepared lozenges. The candy based lozenges were prepared by heating and congealing method in a candy based industry on request with sugar base, Acacia, citric acid artificial flavours and colours and other essential excipients. The prepared medicated lozenges were characterized for drug content uniformity, hardness, thickness, weight variation, friability, moisture content, in vitro disintegration and dissolution by pharmaceutical standard methods. Accelerated stability study conducted as per ICH guidelines (zone IV) at 45°C and 75% relative humidity over a period of seven weeks found that there wasn’t any substantial interaction between the drugs, flavor and color and the prepared formulations were stable.
Keywords:- Clotrimazole, lozenges, oral thrush.
Review article:- *Amartya De, Prof. (Dr.) N.N Bala, Abhijit Bhattacharjee.
Department of Pharmacology, B.C.D.A College OF Pharmacy & Technology, 78 Jessore road (s), Hridaypur, Barasat, Kolkata-700127, West Bengal, India.
Abstract:- Glioblastoma multiforme is an aggressive disabling and deadly disease of the central nervous system. Early detection and treatment improve the prognosis for adults with glioblastoma. Advance practice nurses can help identify patients with glioblastoma multiforme early in the disease process and provide these patients with comprehensive nursing care.In this article we discuss the clinical presentation, diagnosis, postoperative care, treatment, symptom management, health promotion and physicochemical care for patients with glioblastoma multiforme.
Keywords:- Brain tumor, Glioblastoma Multiforme, Glial Cells, Pharmacological Treatment.
Research article:- *R P Mishra1, Mohammad Arshad2 and Abdul Sami2 .
1R&D Division, MRD LifeSciences, Lucknow, Uttar Pradesh, India.
2Integral University, Lucknow, Uttar Pradesh, India.
Abstract:-Rosa indica leaves, stem and flowers were screened against various pathogenic bacterial strains to study the antimicrobial properties of the plant. Methanolic and ethyl acetate extracts of plant parts were screened by agar well diffusion method against E. coli, P. aeuginosa and S. aureus, respectively. Methanolic extracts of rose petals, leaves and stem were found to have good antibacterial properties against the entire test microorganisms selected in the study, while ethyl acetate extract showed activity against P. aeruginosa only. Rose flower was found best source for antibacterial activity against the microorganisms.
Keywords:- Rosa indica, E. coli, S. aureus, antibacterial properties, antibiogram.