DocumentsDate added
Original article:- Gautam Nagori 1 , Rajendra K. Gupta1, Poonam Nagori 2
1 MD, Assistant Professor, Department of Paediatrics,2 MSc Resident, Department of physiology, Jhalawar Medical College, Jhalawar, Rajasthan, India-326001.
Abstract:-
Aim: To identify and co-relate various factors affecting the outcome in children with Scorpion sting envenomation and treatment done by standard protocol using prazosin. Method: This is a prospective study of scorpion sting affected cases in children ( 1-15yrs of age) admitted and treated in dept. of pediatrics , Jhalawar medical college, Rajasthan during the period of January 2010 to December 2011.Permission was taken from Ethical committee of the college before starting the study. Consent was taken from the close relative of the patient. General characteristics of the prazosin. children, anatomic site of the sting, seasonal pattern, clinical and laboratory findings, treatment approaches, complications and outcomes recorded. Result: A total of 61 children of Scorpion sting envenomation admitted in that period. Prevelance of male child’s were found to be 57.3%. Out of them 83.6% cases belongs to rural areas. Extremities were most common site of sting (95%).62% of sting cases occurred in summer months. Local pain, perspiration and cold extremities were seen in almost all cases. The standard treatment followed with the use of prazosin after admission. Mortality seen in only 4.91% of cases. Conclusion: Early hospitalization and administration of accurate dose of prazosin and closely monitoring vitals of the patients in intensive care unit will save many lives.
Keywords:- Scorpion sting envenomation, prazosin, myocarditis, peripheral circulatory failure, pediatric intensive care unit.
Research article:-
* Sayantan Ray1, Noorjaman Rahaman2, Arijit Basu3, Suparna Ghosh Ray4
1Assistant Professor, Department of Pharmaceutical Science, Shivdan Singh Institute of Technology and Management, Aligarh, Uttar Pradesh, India.
2,3Department of Pharmacology, NSHM College of Pharmaceutical Technology, Kolkata, West Bengal, India.
4 Assistant Professor, Department of Radiation Oncology, Burdwan Medical College &Hospital, Burdwan, West Bengal,India.
Abstract: - In the present study, petroleum ether, chloroform and aqueous methanolic extracts of dried leafs of Caralluma fimbriata at the doses of 100 and 200 mg/kg was evaluated for the analgesic activity using the hot plate and acetic acid induced abdominal constrictions in mice. Caralluma fimbriata leaf extract showed significant analgesic properties in all the models studied.
Key Words: Caralluma fimbriata, Analgesic, Hot plate.
Original article:-
* OMOLE, Moses Kayode Pharm. D ADEYEMI, Morenike Titilola B. Pharm.
Department of Clinical Pharmacy and Pharmacy Administration, Faculty of Pharmacy, University of Ibadan.
Abstract:- The requirement for rational use of drug (RUD) is that the right drug be used with the right dose, at the right interval and at the right duration. This study was carried out to determine the rational use of anti-asthmatic drugs and to investigate various factors that influence the selection of such drugs at the University College Hospital (UCH). The study was conducted between the period of two months of May 1st and June 30th, 2010. Four case notes of two male adults and two female adults from the medical out-patient records department were randomly selected and thoroughly studied. Patient A was prescribed 8 drugs including salbutamol and prednisolone as anti-asthmatic drugs. Patient B was prescribed 7 drugs including salbutamol and aminophylline as anti-asthmatic drugs. Patient C was prescribed 4 drugs including salbutamol as anti-asthmatic drug and patient D was prescribed 6 drugs including salbutamol, aminophylline and prednisolone as anti-asthmatic drugs. There was no potential drug interaction or adverse drug reaction documented for the patients. Other complications documented were hypertension and zeazure for patient A, diabetes mellitus for patient B, and chest infection in patient D. Although the patients were discharged and pharmacotherapy individualized, anti-asthmatics which were rationally used in the studies could be implicated by irrational use of drugs in the treatment of other complications.
Key Words:- Asthma, Rational, Prescriptions, Drugs.
original research article:-
*K. Ashok Augustine Raj1, K.Langeswaran2, P. Krishnamoorthy3.
1Assistant Professor in Bioinformatics, 2Assistant Professor in Industrial Biotech, 3Dean-Bioengineering Bharath University, Chennai, TN,India.
Abstract:- The effects of lycopene supplementation on PCB induced endocrine interference caused by PCBs in rat Sertoli cells of PCBs exposed adult rats was investigated. The severity of the endocrine disruption was determined by measuring Traits of reproductive organs; sperm characteristics, testicular histological findings, plasma testosterone levels and the testicular tissue oxidative status were determined. Induction of PCB to rats decreased sperm concentration (p<0.05) and sperm motility (p<0.001), increased total abnormal spermrates (p<0.05) as compared with the control group. An increase in testes malondialdehyde concentrations (p<0.05) and glutathione peroxidase activities (p<0.001) were detected while significant decreases in glutathione levels (p<0.001) in PCB alone group when compared to control group. While pre-treatment with lycopene restoring only malondialdehyde concentrations, its post-treatment caused normalization in both malondialdehyde and glutathione levels when compared with the PCB alone group. On the other hand, significant increases were determined in GSH-Px activities in all experimental groups when compared with the control group. In conclusion, lycopene supplementation was found to be able to diminish the severity of PCB induced endocrine disruption.
Case report:-
* Goyal Amit1, Shivalinga BM2 , Jyothikiran H3.
1MDS, Senior Lecturer,2 MDS, Professor, 3MDS, Associate professor, Department of Orthodontics and Dentofacial Orthopaedics, Guru Nanak Dev Dental College and Research Centre, Sunam, Punjab, India.
Abstract:- This report describes the orthodontic treatment of a 14-year-old boy with missing mandibular first molar. Titanium screw was placed in the buccal alveolar bone between the roots of the first and second premolar to provide absolute anchorage for protraction of the second molar into the atrophic edentulous area. More than 8 mm of protraction was done without significant lingual tipping of the incisors and a good posterior occlusion was achieved.
Keywords:-orthodontic, periodontal, implants.