DocumentsDate added
Research article:-Pathology
*1Deshpande Rangrao H and 2S.K.Wadde. 1,2M.D. Pathology , Department of Pathology, MIMSR Medical College, Latur, India.
Abstract:- Aims & Objectives: Safety of blood is very important. Blood transfusion can cause the transmission of infections to recipients. This is an important mode of infection. The aim of study to assess HCV infection among blood donors. Retrospective study of five years from Jan.2007 to Dec.2011 was done. This study was conducted at Blood bank, MIMSR Medical College Latur, Govt. Medical College, Latur and Bhalchandra Blood bank, Latur. Materials & Methods: Total 10, 4925 donors were tested. Donors were screened for seroprevalence of HCV along with other necessary tests. Screening of HCV was done by Elisa method. Results: The Seroprevalence of HCV was 0.22% in total donors. Conclusion: The Seroprevalence is decreasing from 2007 to 2011 in this study in this type of infection. But it should be noted that maximum donors are voluntary (79.33%) who have donated blood in big blood donation camps. To reduce the seroprevalence still low, the selection of voluntary donors should be of high quality.
Key words:- Seroprevalence, Blood donation, HCV, blood transfusion infections.
Review article:-Pharmacology
Manoj G Tyagi and K Arumugasamy
Department of Pharmacology, Christian Medical College, Vellore 632002, Tamilnadu, India.
Abstract:-Serine protease inhibitors contribute in patho-physiological conditions.An important Serine protease enzyme inhibitor like the Protease nexin-1 (PN-1) is a 43 kDa protein of the serpin superfamily secreted in the extracellular space, where it binds and inhibits several serine proteases, including thrombin, trypsin, plasmin, tPA, and uPA. Its expression is finely regulated both spatially and temporally during development and in adulthood. In vivo, PN-1 regulates proteolytic activity in both the central nervous system (CNS) and peripheral nervous system (PNS). Mechanistically, PN-1 has been shown to promote neurite outgrowth and regulate survival or death of injured neurons. Injury of the rat sciatic nerve triggers PN-1 production in Schwann cells localized at the distal site of the lesion, possibly to protect structures from prolonged and extensive proteolytic attacks.This review reflects on their roles in nervous system disorders.
Key Words:- Protease inhibitor, Protease nexin-1, nerve, skeletal, thrombin.
Research article:-
Soumendra Sahoo1*, Rashmirekha Sahoo 2, Iman El Mehendi 3 ,Musa Abuajila Ahmad 3
1Melaka Manipal Medical College, Melaka, Malaysia. 2Nilai University, Nilai, Malaysia.
3Al Arab Medical Science University, Benghazi, Libya.
Abstract:- Background:- Dicarbonyl compounds such as methylglyoxal and glyoxal have been identified as the predominant source for the formation of advanced glycation end products (AGE) in various tissues contributing to aging and cataract formation in the lens. The aim of the study was to compare the level of reactive dicarbonyls in removed senile cataractous lens nuclei, aqueous humor and plasma of diabetic and non-diabetic cases. Methods: -. This was a cross sectional study done with sample size of 60 senile cataract cases. Half cases were known diabetic while other half non-diabetic. The reactive dicarbonyl levels were detected through UV spectrophotometry. Results: - The mean dicarbonyls level in lens nuclei, aqueous humor and plasma were 888.07 ± 14.95 nmol/L, 2.85 ± 0.44 nmol/L and 2.71 ± 0.44 nmol/L respectively in diabetic individuals where as in non diabetic cases the respective mean levels were 490 ± 8.72 nmol/L, 1.80 ± 0.34 nmol/Land 1.78 ± 0.45 nmol/L (p<0.001). Conclusion: - Diabetic cases were noted to have more browning of their cataractous nuclei. There was a significant elevation of dicarbonyls in the removed nuclei, plasma and in aqueous humor in diabetics.
Key words:-Dicarbonyl, lens nucleus, aqueous humour, diabetic, non-diabetic
Research article:-Pharmaceutical chemistry
Komal Khanpara1*, Renuka2, Dr. V. J. Shukla3, Dr. Rabinarayan Acharya4.
1,2Ph.D.Scholar,3M. Sc. (Chem.), Ph. D.,Head, Pharmaceutical chemistry laboratory,4 Associate Professor,Department of Dravyaguna, I.P.G.T. & R.A. GAU, Jamnagar–361 008, India.
Abstract:- The Astringent taste is important for the sensory quality of Traditional medicines. Perception thresholds of two important Kashaya rasa based compounds – as Kulath and Kachanar, were determined by using different methods of fingerprinting analysis. In planner chromatography elution follows as Ketones and aldehydes approximately in the middle, alcohols behind them and the acids still at the starting point. Well-known drugs having the sequence of separation follows the polarity of the compounds [1] and the taste of separated bands were confirmed by taste-threshold methods. Bitter rasa dominant zone was selected for further TLC fingerprinting and that was used as BRM in further analysis. In present study attempt was made to modulate sample preparation stage using chromatographic fingerprinting for generation of rasa fraction for Kulath and Kachanar. Thus planner chromatography technique seems very important and useful when BRM hypothesis was adjunct to method that explains the categorization acco.to traditional medicine classification method. i.e. Rasa domain classification method.
Key Words:- BRM, Column chromatography, Sensory evaluation, Spectral comparison.
Research article:-Periodontology & Oral Implantology
1*Mallika Sethi, 2Amit Dua, 3Alka Sethi, 4Anuj Sethi ,5Vidya Dodwad.
1M.D.S, Senior Lecturer,5 M.D.S, Prof & Head, Dept. of Periodontology & Oral Implantology, I.T.S Centre for Dental Studies and Research, Delhi –Meerut Road, Muradnagar,India.
2Reader; Department of Prosthodontics Inderprastha dental college; Ghaziabad,India.
3M.S. (Obs & Gynae), Consultant Gynaecologist, Cantt Hospital , Jhansi UP,India.
4(Post Graduate Student 3rd year) M.D Pediatrics , SBKS Medical Institute, Sumandeep Vidyapeeth, Pipariya Vadodara,India.
Abstract:- This paper addresses the problem of adverse pregnancy outcome in relation to periodontal disease. There is compelling evidence that a link exists between pre-term low birth weight and periodontitis. Although 25% to 50% of pre-term low birth weight deliveries occur without any known etiology, there is increasing evidence that infection may play a significant role in preterm delivery. The aim of this review is to summarize known risk factors for preterm low birthweight infants together with some putative mechanisms which may link these risk factors to preterm low birthweight. Current evidence has pointed to an interest in dental intervention studies to control periodontal disease as one of the potential strategies to reduce pre-term labour. This paper reviews the potential association between periodontal infection and preterm low birth weight infants.
Key Words: -Low Birth Weight, Preterm birth, Periodontal disease.