DocumentsDate added
Case report:-
Kunwarjeet Singh1, Himanshu Aeran2, Narendra Kumar3 and Nidhi gupta4
1Reader, Department of Prosthodontics and implantology, 3 Professor, Department of Prosthodontics and implantology,4 Reader, Department of Pedodontics and Preventive DentistryInstitute of Dental Studies and Technologies, Modinagar, Ghaziabad, Uttar Pradesh, Indai.
2Professor,Department of Prosthodontics and implantology,Seema dental college,Rishi Kesh, uttar Pradesh, India.
Abstract:- Aims and objectives: Making of definitive/secondary impression of displaceable flabby tissues with minimum or no displacement of tissue by using window impression technique. Background: Displaceable, flabby or hyperplastic tissues or commonly seen in the anterior region of edentulous maxilla opposing mandibular anterior natural teeth or in the mandibular alveolar ridge when extensive bone resorption has occurred. Prevalence of flabby ridges can vary, occurring in up to 24% of edentulous maxilla and in 5% of edentulous mandible. Displacement of flabby tissues during impression making is always a concern. Soft tissues that are displaced during impression making tend to return to their original form, and complete dentures fabricated from such impression will not accurately fit on the recovered tissues resulting in loss of retention, stability and occlusal disharmony the dentures. Materials and Methods: This technique uses a custom tray with a window over mobile tissues and a mucostatic impression material to minimize distortion of tissues while making impression. First an accurate record of the denture supporting and limiting structure is made except for the mobile tissues which are recorded in second step using light body polyvinyl siloxane impression material in the window area of special tray. Conclusion: The use of this technique helps in maintaining the contour and recording the detail of the tissues without displacing the flabby tissues. Hence it improves the prognosis for complete denture without surgical removal of hyperplastic tissues.
Key words:- Window impression technique, flabby ridge, polyvinyl siloxane, hypermobile tissues, Mucostatic, light body.
Research article:-Biochemistry
Lawal, A*1., Umar, R. A1.,Abubakar, M. G1., Faruk, U. Z2. and Wali, U3
1Department of Biochemistry, 2Department of Pure and Applied Chemistry, 3Chemical Pathology Department, School of Medical Laboratory Science, Usmanu Danfodiyo University, Sokoto-Nigeria.
Abstract:- FTIR is a simple, reproducible technique and most widely used methods for structural elucidation of many chemical compounds, and has been used as a requisite method to identify medicines in different pharmacopoeias. Pellets were prepared by taken 0.150 g of Potassium Bromide (KBr) and mixed with 0.008 g of the reference standards of artemisinin and its derivatives artesunate each and the spectra were recorded between 4000 cm-1 and 500 cm-1, by averaging 10 scans for each spectrum with a Shimadzu FT-IR Spectrophotometer. The fingerprints obtained exhibit the presence of C – H bend, C = O stretch, aromatic C – H in plane; cyclic ethers, large rings, C – O stretch and peroxides, C – O – O – stretch respectively. Additional IR-bands were observed of CH2 – CH2, cyclohexane ring vibration, and ester in artesunate. Also, simple and sensitive Spectrophotometric methods of these antimalarial were developed using methylene blue and soluble starch as chromogenic agents in pure forms of artemisinin (ATM) and artesunate (ATS) and in formulations. The results obtained for calibration curve show that r2 were 0.9602 and 0.9996 for ATM and using methylene blue while 0.9537 and 0.9648 for ATM and ATS using soluble starch as chromogenic agent respectively. The intra- and inter-day precisions were within 48.7 to 96.6% relative standard deviations. Limits of detection and quantification were found to be within accepted range. In post-developmental and validation phases, drugs were sample and tested and the results reveal percent content of API of the drugs between 78 -105% for spectrophotometric methods. Conclusively, the results showed that the proposed methods could be used in determine these antimalarial in formulations.
Key words:- IR fingerprints, methylene blue, soluble starch, artemisinin and artesunate.
Case Report
Kunwarjeet Singh1, Nidhi Gupta2* Neesha Chowdhary3 and Vikram Kapoor4.
1Reader, 3,4 Senior lecturer, Department of Prosthodontics and Dental Materials,2Reader, Department of Pedodontics and Preventive Dentistry, Institute of Dental Studies and Technologies, Modinagar, Ghaziabad, Uttar Pradesh, India.
Abstract:- The goal of a Prosthodontists is to control oral disease while restoring esthetics and function with durable and biocompatible restorations. Knowledge of the response of periodontal tissues to artificial crowns and fixed partial dentures is crucial in the development of treatment plan with predictable prognosis. Crowns and FPDs increases the incidence of gingival inflammation adjacent to restorations, particularly if restoration rests on free gingiva, has sub-gingival finish line, poor marginal adaptation or improper crown contours. The periodontium of the tooth to be restored should be healthy before starting the restorative procedure. The successful functional and esthetic rehabilitation of tooth with predictable prognosis depends on establishing a physiologic periodontal climate and facilitation of maintenance of periodontal health. This case report describes the effects of tooth preparation procedure and poorly designed crowns on health of adjacent periodontal tissues and esthetics.
Key words:- Periodontium, Esthetics and functional rehabilitation, mutilated tooth, crown contour, smile zone, emergence profile.
Original article:-Pharmacology
Chandel Nitibhushansingh R1, Phadke Anant G2 and Goyal Chhaya A3
1M.D. (Pharmacology), Assistant Professor, 3M.D( Pharmacology), Professor, Department of Pharmacology, SAIMS Medical College & PG Institute, Indore, Madhya Pradesh, India. 2M.D.(Pharmacology), Professor, Department of Pharmacology, JNMC, Sawangi (Meghe), Wardha, India.
Abstract:- Aim: To study the interaction of calcium channel blocker (verapamil) with Antipsychotic drug (Haloperidol) in CAR and catalepsy models in rats.
Methods and Results: Every group consisted of 10 healthy albino rats of either sex. Different groups received Verapamil (5, 10 &20 mg/kg, i.p.), Haloperidol (ED50 -0.2mg/kg) alone and combined doses of both drugs. The Antipsychotic effect of drugs was measured by Conditioned avoidance response (CAR) using Cook’s Pole climbing apparatus and Adverse drug effect (Extra pyramidal syndrome) was measured by Catalepsy. 5 mg/kg i.p. of Verapamil inhibited CAR in 50 % of Rats (compared to control, p<0.001). 10mg/kg i.p. of verapamil inhibited CAR in 70% of Rats (p<0.001) & 20 mg/kg i.p. inhibited CAR in 80% of Rats (p<0.001). When verapamil (5 mg/kg i.p) was combined with Haloperidol ED50-0.2mg/kg the CAR was inhibited in 80% of the rats (p<0.001) and after combining verapamil (10mg/kg) with Haloperidol ED50-0.2mg/kg the CAR was inhibited in 100% Rats. (p<0.001) Verapamil at the dose of 5 mg/kg and 10 mg/kg (i.p.) did not induce catalepsy in the rats at any testing time interval. At 20 mg/kg i.p., it produced catalepsy in 3 rats at half hour and in 5 rats at 1 hour and 2 hour testing interval each.(p<0.01). Verapamil pretreatment in the dose of 5 mg/kg did not affect the haloperidol (ED50 -0.4 mg/kg) induced catalepsy. In the dose of 10 and 20 mg/kg, pretreatment with verapamil significantly increased cataleptic scores at all testing intervals (P<0.05).Conclusion: Verapamil blocked CAR. Its higher doses induced catalepsy and it is synergistic with haloperidol in blockade of CAR and catalepsy.
Key words:- Verapamil, Haloperidol, Conditioned avoidance response (CAR), Catalepsy.
Original article:-Community Medicine
Rituja Kaushal1, Neeraj Gour2*,Sanjay Kumar Gupta3, Arvind V Athawale4,M S Pathak5, P Tripathi6 and K Kaushal7.
1Post Graduate Resident,2Assistant Professor,3Associate Professor,4Professor and Head,5Associate Professor ,Department of Community Medicine, Peoples College of Medical Sciences & Research Centre Bhopal, M.P ,India.
6District Malaria Officer,Bhopal,M.P,India.
7Ex Superintendent,PMC, Bhopal,M.P ,India.
Abstract:- After years of fight against Malaria-a major public health problem, various states of India have started achieving success in controlling & preventing malaria transmission by implementing a broader mix of interventions. This observational secondary data based study was undertaken to assess the success achieved by District Malaria Centre, Bhopal in terms of various epidemiological surveillance parameters like API,ABER,SPR,SFR, Pf% etc. Overall a declining trend was found more or less among all epidemiological parameters which itself somehow by far reflect the quality of efforts put by district health officials and health workers. This study also demands a multicentre qualitative research in this aspect to explore what efforts and reasons have been responsible for this decline in various malariomatric parameters.
Key words:- Bhopal; malariomatric parameters; trend.