DocumentsDate added
Short communication:-Microbiology
Bindu D*, Illamani V, Chitralekha S, Kiran Madhusudhan, Praveena R.
Department of Microbiology, Sree Balaji Medical College & Hospital, Chromepet Chennai (Bharath University),Chennai,India.
Abstract:- Urinary tract infection (UTI) is a common community acquired infection. Due to rising antibiotic resistance among uropathogens, especially in gram negative bacteria, it is important to have knowledge of antibiogram of these organisms. This study retrospectively analyses the antibiogram among the gram negative urine isolates during 7 months in patients with UTI. Out of 59 uropathogens, the common isolates were Escherichia coli 41 (69%), Klebsiella spp. 15(21%) and Pseudomonas spp. 3 (5%). The results have showed high level of susceptibility to aminoglycosides . More 40 isolates were resistant to cephalosporins, aztreonam, norfloxacin, nalidixic acid, ciprofloxacin and ofloxacin. This result shows high level of resistance to cephalosporins.
Keywords:- Urinary tract infection (UTI), Extended Spectrum β-Lactamases (ESBL), Antibiogram.
Research article:- Medicine,
Krithika D Muralidhara1*, Prabha Adhikari2, Kotian MS3 & Muralidhara DV4
1MBBS, MD, (Senior Registrar), Fr Muller Medical College, Mangalore, India.
2MBBS, MD, Professor of Medicine, Kasturba Medical College, Mangalore, India.
3MSc, Asst Professor, Dept of Community Medicine, Kasturba Medical College, Mangalore, India.
4PhD, Professor of Physiology, Faculty of Medicine and Health Sciences, University Sultan Zainal Abidin, Kuala Terengganu, Malaysia.
Abstract:- Polycystic ovarian syndrome (PCOS) is considered as a multisystem endocrinopathy. The present investigation on eighty five (85) patients diagnosed with PCOS revealed that 78% of them were overweight or obese on the basis body mass index. This fact was also partly supported by higher waist circumference in a majority of them indicating central obesity. Body weight gain at puberty was reported by over 80% of the subjects and elevated blood pressure was associated with abnormal lipid profile in a large number. Overweight/obese subjects had slightly higher fasting blood sugar levels. Metabolic syndrome features were thus evident in 33% of the subjects. However, only 4% of the subjects were infertile. Clinically, almost all subjects had developed hirsuitism and 40-70% of them had Cushingoid features. Hormonal functions such as insulin, LH/FSH ratio, male hormones, particularly dehydroepiandrosterone sulfate was higher in a considerable number of patients. 40% of the patients had hypothyroid features. The findings of study thus also support the idea that PCOS may be a manifestation of metabolic syndrome as suggested by others.
Key words:- Polycystic ovary syndrome, metabolic syndrome, obesity.
Case report:- Microbiology
Lakshmi K1, Nagarajan Krishnan2, Santhanam Rengarajan3*.
1Assistant Professor, Department of Microbiology, 2Associate Professor, Department of Radiology, 3Associate Professor, Department of Neurosurgery,Sree Balaji Medical College and Hospital, Chennai, India.
Abstract:- Cerebrospinal fluid (CSF) rhinorrhea is a known complication of medical therapy with dopamine agonists in case of prolactinomas, radiotherapy or Postsurgical. But it is an extremely rare presenting symptom of an untreated non functional pituitary macroadenoma. We report one such rare case of a forty six year old man with moderately-sized non-functioning pituitary macroadenoma presenting with spontaneous CSF rhinorrhoea. CT (Computed Tomography) showed an isodense sellar -suprasellar lesion with minimal contrast enhancement and asymmetrically dilated ventricles - left more than the right. MRI (Magnetic Resonance Imaging) revealed an isointense lesion with extension into the third ventricle superiorly, and sphenoid and posterior ethmoid inferiorly through bony defect in sellar floor with asymmetrically dilated ventricles. Patient underwent left ventriculo-peritoneal shunt followed by endoscopic transnasal decompression. Biopsy of the lesion confirmed pituitary adenoma. Patient had good clinical outcome and is asymptomatic in the past three years of follow up.
Keywords:-Hydrocephalus, Pituitary macroadenoma, Spontaneous CSF rhinorroea.
Research article:- Biochemistry, & Bioinformatics
Paramasivam Ragavendran1, Murugan Muthu1, Chintamony Arul Raj1, Dominic Sophia1, Thangarajan Starlin2, Balasubramanian Vidya1, Palanisamy Chella Perumal2 & Velliyur Kanniappan Gopalakrishnan1,2*.
1Department of Biochemistry, Karpagam University, Coimbatore, Tamilnadu, India 641 021. 2Department of Bioinformatics, Karpagam University, Coimbatore, Tamilnadu, India, 641 021.
Abstract:- Aerva lanata (A. lanata) L. is an ayurvedic medicinal plant, found throughout tropical India as a common weed in fields and wasteland. In this study, to evaluate the HPTLC fingerprinting analysis of bioactive compounds for the identification and conformation analysis of aqueous, ethanol and aqueous ethanol extract of A.lanata. Quantification of these bioactive compounds are carried out, after that these extracts undergo the analysis of HPTLC profile of flavanoid, phenols, tannins, terpenoids and glycosides. All the three extracts of A.lanata has flavanoid, phenolics, tannins, terpenoids and glycosides. But terpenoids are not present in aqueous extract. The present study supplements the folkloric usage of the studied plants which possess known and unknown bioactive compounds with bioactivity. By isolating and identifying of these compounds can be formulated to treat diseases. This plant can be utilized as useful herb for alleviation of various illness and disorder.
Key words:- Aerva lanata, HPTLC fingerprinting, Flavanoid, Phenolics, Tannins