DocumentsDate added
Case report
Ramya G1,Banushree C Srinivasamurthy2*,Mutharasu1& Deepti Jose1
Affiliation:-
1Postgraduate student, 2Associate Professor, Department of pathology, Sri Manakula Vinayagar Medical College, Madagadipet,Puducherry-605107,India.
Abstract:
β-Thalassaemias are very heterogeneous, both in the molecular defects and the clinical manifestation. Subjects with thalassemia trait, also known as carriers, have low mean corpuscular volume, low mean corpuscular hemoglobin, and increased hemoglobin A2. With approximately 7% of the worldwide population being carriers, hemoglobinopathies are the most common monogenic diseases and one of the world’s major health problems. Adequate care of the affected patients requires a wide variety of diagnostic and therapeutic measures. Thalassaemia minor (carrier) is generally asymptomatic and usually does not present with any significant symptoms. We describe a case of thalassemia minor in a 20year old female presenting with jaundice, giddiness, fever and peripheral smear suggesting hemolytic anemia and increased hemoglobin A2 on HPLC.
Key Words: Beta-thalassemia; thalassemia minor; hemolytic anemia; hemoglobin A2.
References:
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Copyright © 2013 Banushree CS et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Case report
Amrit Kaur Kaler1*, Roopa AN.2, Subramanyam H2,
Shameem Shariff3, & Kusuma4
Affiliation:-
*1Assistant Professor of Pathology,2Associate Professor of Pathology,3Professor of Pathology, 4Post graduate student, MVJ Medical College & Research Hospital, Bangalore, Karnataka, India. 560029.
Abstract:
Complex Fibroadenoma (CF) is a subtype of fibroadenoma harbouring one or more complex features, including epithelial calcifications, papillary apocrine metaplasia, sclerosing adenosis, and cysts larger than 3 mm. These neoplasms tend to occur in the older patients. CF is usually smaller than a fibroadenoma and represents a degenerative change over a period of years. A case of CF is reported in which the mass was hard and gritty on cut section, measuring 7x6x6 cms, involving the entire breast and mimicking a carcinoma. The present case is reported in order to make the pathologists aware of this variant and to emphasize that complex fibroadenoma should be considered in differential diagnosis of breast lesions as it carries 3.1 times higher risk of malignancy as compared to the general population. This article also emphasizes on the various patterns seen on complex fibroadenoma. Also proposed are the follow up criteria for the management of these patients.
Key Words: Complex Fibroadenoma; neoplasms, malignancy.
References:-
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6.Gordon PB, Gagnon FA, Lanzkowsky L. Solid breast masses diagnosed as fibroadenoma at fine-needle aspiration biopsy: acceptable rates of growth at long-term follow-up. Radiology 2003; 229: 233-8.
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Article citation:-
Amrit Kaur Kaler, Roopa AN, Subramanyam H, Shameem Shariff, & Kusuma. Complex fibroadenoma: A most neglected variant of fibroadenoma. Journal of pharmaceutical and biomedical sciences (J Pharm Biomed Sci.) 2013 May (Supplement 1); 30(30): S36-S39. Available at http://www.jpbms.info
Copyright © 2013 Amrit Kaur Kaler, Roopa AN.,Subramanyam H,Shameem Shariff, & Kusuma. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original article
1SANNI, Momoh, *1EJEMBI, Daniel, 2EMMANUEL, T. Friday,
1ABBAH, Okpachi C &1 OGALA, Emmanuel
Affiliation:-
1Department of biochemistry, Kogi State University, Anyigba, Nigeria.
2Department of medical biochemistry, Kogi State University, Anyigba, Nigeria.
Author’s contributions-All authors contributed equally to this paper.
Abstract:
The effects of chronic administration of Indomie instant noodles on the activities of alanine aminotransferase (ALT) of rat kidney was investigated. Fourty-eight (48) rats (both males and females) of average weight 210g were divided into seven groups. Each group consists of three (3) rats each, except for the control, which consists six (6) rats (i.e both the males and the females).The rats in group I, for both sex, were administered cooked indomie spiced with the seasoning, group II, were given raw indomie spiced with the seasoning, group III, were given both the cooked and raw indomie mixed together and spiced with the seasoning, group IV, were given cooked indomie without the seasoning, group V, were given raw indomie without the seasoning, group VI, were given both the cooked and raw indomie, mixed together, without the seasoning and, group VII, which served as the control, were given the normal fowl formulation feed. The administration was carried out for a period of four (4) weeks, the result showed that, there was a decrease in kidney activity of the enzyme.
Key words: Indomie instant noodles; Alkaline phosphatase.
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Article citation:-
Sanni et al. Effects of chronic administration of indomie noodles on the activity of alanine aminotransferase of rat kidney. Journal of pharmaceutical and biomedical sciences (J Pharm Biomed Sci.) 2013 May(Supplement 1);30(30): S65-S71.Available at http://www.jpbms.info
Copyright © 2013 Sanni et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original article:
*1Harsha T R, 2Vijaya D & 3Nagarathnamma T
Affiliations:
1Assistant professor, Department of Microbiology, Victoria hospital, Bangalore Medical College, Bangalore, Karnataka, India.
2Professor and Head, Department of Microbiology, Adichunchangiri Institute of Medical Sciences, Karnataka, India.
3Professor and Head, Department of Microbiology, Bangalore Medical College, Karnataka, India.
Abstract:
Background and objective: Urinary tract infections (UTI) are the most common bacterial infections and account for significant morbidity and health care costs. Antibiotics are usually prescribed empirically before the laboratory results of urine culture are available. Due to rising antibiotic resistance among uropathogens, it is important to have local hospital based knowledge of the organisms causing UTI and their antibiotic sensitivity patterns. This information would be relevant not only to the local hospital but would also be a vital regional database.
Methods: A total of 600 urine samples from suspected cases of UTI referred from various departments of Bowring & Lady Curzon Hospital formed the study group. Samples are subjected to microscopy and culture. Isolates were identified by a battery of biochemical tests. Conventional method of antibiotic susceptibility was done by Kirby Bauer disc diffusion method and Rapid method by Mini API.
Results: UTI’s were more common in the age group of ≤10 years (24.16%) and in females (53.44%). 32.6% cases were from the inpatients and 67.4% from outpatient departments. Out of 600 cases studied, 69 cases (11.5%) yielded significant bacteriuria. Escherichia coli was the most common uropathogen isolated (73.9%) followed by Klebsiella spp (24.6%), and Citrobacter spp (1.4%). E. coli was 100% sensitive to amikacin and imipenem and highly resistant to ampicillin (19.6%), norfloxacin (15.6%). Klebsiella spp were highly sensitive to imipenem (100%) and piperacillin/tazobactum (82.3%) and resistant to ampicillin (5.8%), cefotaxime (17.6%). Citrobacter spp was sensitive to imipenem alone. Antibiotic susceptibility pattern obtained by conventional method is in correlation with the rapid method (MINI API).
Conclusion: The rapid method for antibiotic susceptibility testing by Mini API is technically simple, reliable (results are similar to disk diffusion method), early reporting (within 48 hours), and cost effective.
Key Words: Urinary tract infection; E.coli; Mini API.
References:
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Copyright © 2013 Harsha T R. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original article
Fadya Y. Al-Hamdani*
Affiliation:-
*Lecturer, College of pharmacy, Baghdad university, Ba-almoadham,P.O.Box14026, Iraq.
Abstract:
Community pharmacist is an only health care professional who will interact with several individuals each day and can make successful efforts to educate the patients and guide him about the disease, drugs and lifestyle modification.
Aims: To evaluate the professional role of the community pharmacist and general practitioner during the dispensing process on issues other than the legality or simple clarification of the prescription.
Methodology: Thirty (30) community pharmacists from three adjacent localities completed details of each community pharmacy, during the dispensing of a prescription, the following data were observed: Brief pharmacy details, the prescribed drug therapy, the way and manner of the pharmacist, the outcome and the time taken, category of the drug involved and the time taken and other certain roles. A questionnaire paper was distributed to these pharmacists filled up by them while making a semi structured interview with them to assess their commitment to the basic roles. These assessments were ranked between 10% and 100%.
Results and discussion: The results were established as a mean scores that were excellent regarding some roles and other were bad comparable to ideal roles submitted by many authorized committees or administrations mentioned in this project.
Conclusion and recommendation: Clinical pharmacy provided by a community pharmacist during the dispensing process has the potential to provide a valuable contribution, but needs a further commitment from the pharmacist to enhance the health care.
Key words: Community pharmacist; clinical pharmacy; pharmacy; prescription drugs.
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Conflict of interest: - Author has not declared any conflict of interest.
Source of funding: - None.
*Correspondence address:
Fadya Y. Al-Hamdani.,
Lecturer,
College of pharmacy, Baghdad University, Ba-almoadham, P.O.Box14026, Iraq.
Copyright © 2013 Fadya Y. Al-Hamdani. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.