March 2015;05(10) issue of the J Pharm Biomed Sci.
DocumentsDate added
Original article
Nirmalya Nirbisank1,*, Ranjit Kumar Mishra1,¥,D.N Panda1,±,Swarupjit Ghata1
Affiliation:
1Third Year P.G Student, 1,¥M.S, Professor and HOD,1,± M.S. Professor, Department of General Surgery, Hi-Tech Medical College and Hospital, Bhubaneswar, Odisha, India
The name of the department(s) and institution(s) to which the work should be attributed:
Department of General surgery, Hi-Tech Medical College and Hospital, Bhubaneswar, Odisha, India
Address reprint requests to
Dr. Nirmalya Nirbisank.
3rd year PG student, department of General surgery, Hitech medical college and hospital, Bhubaneshwar, Orissa, India
Article citation:
Nirbisank N, Mishra RK, Panda DN, Ghata S. Impact of varicocele surgery on semen parameters. J Pharm Biomed Sci. 2015; 05(03):238-242. Available at www.jpbms.info
ABSTRACT:
Background: Varicoceles are abnormally dilated veins in the pampiniform plexus. They are the most commonly seen and correctable cause of male factor infertility. Varicoceles have an incidence of 4.4-22.6% in the general population, 21-41% in men with primary infertility, and 75-81% in men with secondary infertility. The surprisingly high incidence in secondary infertility suggests that varicoceles cause progressive decline in testicular function over a perod of time.
Material and Methods: It is a prospective study on the impact of varicoceles on semen parameters. The data collected for our study included patients from Hitech medical college and hospitals, Bhubaneswar, Odisha during the period from August 2012 to November 2014.Patients clinically diagnosed to have unilateral or bilateral varicoceles were included in the study.
Results: The study was conducted on thirty two cases who were posted for surgery for varicocele at Hitech medical college and hospital Bhubaneshwar. Out of 32 cases referred to us thirty were married and two were unmarried.
Conclusion: While most men with varicoceles are able to father children, an abundance of evidence shows that varicoceles are detrimental to male fertility and surgical correction offers an improvement in a couple’s chances of obtaining a pregnancy, either spontaneously or through assisted reproductive technologies.
KEYWORDS: Solitary nodule thyroid; fine needle aspiration cytology (FNAC); thyrid nodule histopathological examination.
REFERENCES
1.Kolettis PN, et al. Evaluation of the subfertile man. Am Fam Physician 2003; 67: 2165-72.
2.Baker HW, et al. Male infertility, Endocrinol Metab Clin North Am 1994;23:783-793.
3.Nieschlag E, et al. Classification of andrological disorders. In: Nieschlag E, Behre HM, editors. Andrology. Berlin, Heildelberg, New York: Spriger-Verlag;1997.pp. 79-83.
4.Russell JK,et al. Varicocele in groups of fertile and subfertile males.Br Med J 1954;1:1231-1233.
5.Dublin L,Amelar RD,et al.Etiologic factors in 1294 consecutive cases of male infertility.Fertil Steril 1971;22:469-74.
6.Saypol DC et al. Varicocele.J Androl.1981;2:61-71.
7.Marmar JL et al. The pathophysiology of varicoceles in the light of current molecular and genetic information. Hum Reprod Update 2001;7:461-72.
8.Tulloch WS, et al.Varicocele in sub fertility:results of treatment.Br Med J.1955;2:356-8.
Statement of Originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Source of funding: None
Competing interest / Conflict of interest: The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
Copyright © 2015 Nirbisank N,Mishra RK,Panda DN,Ghata S. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Research article
Nimarpreet Kaur1,* MD Physiology, Hatinder Jeetsingh Sethi2 MD Internal Medicine, Arti Chopra3 DNB OBG, Neeraj Aggarwal4 DNB Surgery,Dimple Bajaj5.
Affiliation:
1Department of Physiology, SHKM, Government Medical College, Nalhar, Mewat, Haryana 122107, India
2Consultant, Department of Internal Medicine, Medanta, The Medicity, Gurgaon, Haryana 122001, India
3Consultant, Obstetrics and Gynaecology, Asian Multispecialty Hospital, Ludhiana 141002, Punjab, India
4Consultant Surgery, Asian Multispecialty Hospital, Ludhiana 141002, Punjab, India
5Associate Professor, SGRD, Department of Physiology, Amritsar, Punjab, India
The name of the department(s) and institution(s) to which the work should be attributed:
1.Asian Multispecialty Hospital, Ludhiana 141002, Punjab, India
2.SHKM, Govt Medical College, Nalhar, Mewat, Haryana 122107, India
3.Medanta, The Medicity, Gurgaon, Haryana 122001, India
Address reprint requests to
Dr. Nimarpreet Kaur.
SHKM, Govt Medical College, Nalhar, Mewat, Haryana 122107, India
Article citation:
Kaur N, Sethi HJS , Chopra A, Aggarwal N. Comparison of autonomic symptom profile – hidden indicator for detection of autonomic neuropathy - In Type 1 & Type 2. J Pharm Biomed Sci. 2015; 05(03):196-202. Available at www.jpbms.info
ABSTRACT:
Diabetes mellitus is a syndrome with disordered metabolism and inappropriate hyperglycemia due to either a deficiency of insulin secretion or to a combination of insulin resistance and inadequate insulin secretion to compensate. A wide variety of complications affecting the central and peripheral nervous systems - either directly or indirectly - may be encountered in patients with diabetes mellitus. Autonomic neuropathy is a well-recognized complication of diabetes mellitus . The clinical manifestations of diabetic autonomic neuropathy (DAN) includes postural hypotension, gastrointestinal symptoms, hypoglycemic unawareness and sweating disturbances as assessed by autonomic symptom profile i.e CASS score. These clinical manifestations are slowly progressive, usually irreversible and are associated with considerable mortality.
Aims & objectives: Aim of the study is to assess that autonomic symptom profile is an early indicator for development of autonomic neuropathic changes in Type 1 diabetes mellitus as compared to Type 2 diabetes patients.
Materials & Methods: 100 diabetic patients were taken, 50 Type 1 & 50 Type 2.Autonomic symptom profile was assessed by a set of questionnaire asked from the patients and following that various autonomic system tests were done.
Results: The autonomic symptom profile was assessed. It was observed that the various symptoms i.e. orthostatic hypotension, impaired sweating, peripheral vasomotor dysfunction, nocturnal diarrhea, abnormalities in micturation, pupillary dysfunction were more prevalent in Type 1 diabetes mellitus while erectile dysfunctions more prevalent in Type 2 diabetes mellitus
Conclusion: The present study was conducted to compare the autonomic neuropathic changes in Type 1 and Type 2 Diabetes Mellitus with the emphasis on autonomic symptom profile.
KEYWORDS: CASS score; Autonomic neuropathy; Orthostatic Hypotension; Peripheral Vasomotor Dysfunction.
REFERENCES
1.Watkins P J, Thomas P K . Diabetes mellitus and the nervous system. JNeurol Neurosurg Psychiatry 1998; 65: 620–32.
2.Maser RE, Autonomic Neuropathy: Patient Care. Diabetes Spectrum 1998; 11 (4) : 224-7.
3.Mukkamala R, Mathias JM, Mullen TJ, Cohen RJ, Freeman R. System identification of closed-loop cardiovascular control mechanisms: diabetic autonomic neuropathy. Am J Physiol Regulatory Integrative Comp Physiol 1999; 276: 905-12.
4.Goldstein DS, Robertson D, Esler M, Straus SE and Eisenhofer G. Dysautonomias: clinical disorders of autonomic nervous system. Ann Intern Med 2002; 137: 753-63.
5.Williams G, Todd J. A. Diabetes and Genetics of diabetes.In : Warrell David A., Cox Timothy M, John D. Firth, Edward J, J R., M.D. Benz, et al, editors. Oxford Textbook of Medicine. 4th ed . U.K: Oxford Press; 2003: p.1305-10.
6.Low PA, Larson LMB, Sletten DM, Gehrking TLO, Weigand SD, O’Brien PC, et al. Autonomic symptoms and Diabetic Neuropathy: A population-based study. Diabetes Care 2004; 27(12): 2942-7.
7.Tuomi T. Type 1 and Type2Diabetes What do they have in common? Diabetes 2005; 54(2): 40-5.
8.Lafitte MJ, Genoulaz MF, Srikanta SS, Punitha L and Vidyanand S. 500 Heart beats for assessing diabetic autonomic neuropathy. Int. J. Diab. Deb. Countries 2005; 25: 113-7.
9.Rolim LCSP, Chacra AR, Dib SA. Diabetic neuropathies heterogeneity in type 1 and type 2 diabetes mellitus with the same pattern of glycemic control. Diabetes. 2006; 55: 508.
10.Liatis S, Marinou K, Tentolouris N, Pagoni S and Katsliambros N. usefulness of a new indicator test for the diagnosis of peripheral and autonomic neuropathy in patients with diabetes mellitus. Diabet. Med. 2007; 24: 1375-80.
11.McPhee S.J, Papadakis M.A , Gonzales R, Zeiger R editors. Diabetes MellitusandHypoglycemia . In Current Medical Diagnosis & Treatment. 48ed USA: McGraw Hill Companies; 2009.
Statement of Originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Source of funding: None
Competing interest / Conflict of interest: The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
Copyright © 2015 Kaur N, Sethi HJS, Chopra A, Aggarwal N. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Research article
Amrit Anand1,*,Rajlaxmi Panigrahi2,Rajesh Kumar Padhy2
Affiliation:
1Junior resident, 2Associate Professor, Department of ENT, Hi-Tech Medical College & Hospital Pandara, Rasulgarh, Bhubaneswa, Odisha-751025, India
The name of the department(s) and institution(s) to which the work should be attributed:
Department of ENT, Hi-Tech Medical College & Hospital Pandara, Rasulgarh, Bhubaneswa, Odisha-751025, India
Address reprint requests to
* Dr. Amrit Anand.
Plot no. 516/1702, Sub Plot no. 1, Lane No. 2, Phase 4, Adarsha Vihar, Patia-751024), India
Article citation:
Anand A, Panigrahi R, Padhy KR. Clinical and bacteriological study of chronic suppurative otitis media by anaerobic culture methods in HI-Tech medical college and Hospital Bhubaneswar, India. J Pharm Biomed Sci. 2015; 05(03):267-271. Available at www.jpbms.info
ABSTRACT:
Aims & Objective: To observe the types of organisms grown in CSOM both Tubotympanic (TT) and Atticoantral (AA) type.
Material and Methods: This was a prospective study conducted between October 2012 to September 2014 in HI-TECH MEDICAL COLLEGE AND HOSPITAL BHUBANESWAR.120 chronic and actively discharging ears of 100 pateints were included in study
Results: Majority of patients were in age range 26 to 35 years. 69 % of patients were from low socioeconomic group. CSOM-TT was found in 81.67% and CSOM-AA in 18.88% cases. Out of 120 swabs only 113 swabs grew bacteria. Out of 120 swabs, 48.35% swabs grew monomicrobial isolates and 48.83% swabs grew polymicobial isolates. Aerobic growth was seen in 48.33 anaerobic growth was seen in 2.5 % and mixed flora was seen in 43.34% and no growth was seen in 5.83%. In COSM-TT commonest anaerobic was prevotella where as peptostreptococcus was common in CSOM-AA.
Conclusion: In COSM-TT commonest anaerobic was prevotella where as peptostreptococcus was common in CSOM-AA.
KEYWORDS: Bacteriological study; Chronic Suppurative otitis media; Culture.
Statement of Originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
REFERENCES
1.Bluestone CD, Gates GA, Klein JO et al., Definitions, terminology and classification of otitis media. Annals of Otology, Rhinology and Laryngology.2002;111: 8-18.
2.Healy GB, Rosbe KW. Otitis media and middle ear effusions. In: Snow, Ballenger JJ, Editors. Ballengers Otolaryngology Head Neck Surgery.(16th ed). BC Decker INC; 2003: 249-60.
3.Loy AHC et al., Microbiology of Chronic Suppurative Otitis Media in Singapore; Singapore Med J 2002;43(6): 296-299.
4.Srivastava A, Singh R.K et al., Microbiological evaluation of active tubotympanic type of chronic suppurative otits media. Nepalese Journal of ENT Head & Neck Surgery 2010;1(2):14-16.
5.Poorey VK, Arati Iyer. Study of bacterial flora in CSOM and its clinical significance; Indian Journal of Otolaryngology and Head and Neck Surgery 2002;54(2): 91-95.
6.Asif Alam gul, Liaqat ali, Ejaz Rahim, Shakeel Ahmed.Chronic suppurative otitis media; frequency of pseudomonas aeruginosa in patients and its sensitivity to various antibiotics. Professional medical J 2007; 14(3): 411-415.
7.Jonsson L, Schwan A,Thomander L, Fabain P. Aerobic and anaerobic bacteria in chronic suppurative otitis media. A quantitative study. Acta Otolaryngol 1986 :102(5-6):410-4.
8.Erkan et al. Bactriology of chronic suoourative otitis media annals otol rhinol laryngol 1994;103: 771-774.
9.Jagdish Kumar S.A., A comparative bacteriological study in ASOM and CSOM” Dissertation submitted to Bangalore university (1984) unpublished data.
Source of funding: None
Competing interest / Conflict of interest: The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
Copyright © 2015 Anand A, Panigrahi R, Padhy KR. This is an open access article under the CCBY-NC-SA license (http://creativecommons.org/licenses/by-nc-sa/3.0/). which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Case report
B.Deepikalakshmi 1,*, M.Mahalakshmi1, A.C.Vinod1, C.Krithika1,¥,
Ramachandran Sudarshan1,†, S.C.Selvamuthukumar1,β
Affiliation:
1Post graduate student,1,¥ Professor,1,†Senior Lecturer,1,β Professor and Head, Department of Oral Medicine and Radiology, Thai Moogambigai Dental College and Hospital, Chennai, India
The name of the department(s) and institution(s) to which the work should be attributed:
Department of Oral Medicine and Radiology, Thai Moogambigai Dental College and Hospital, Chennai, India
Address reprint requests to
* Dr.B.Deepikalakshmi,
Post graduate student,
Department of Oral Medicine and Radiology,
Thai Moogambigai Dental College and Hospital,
Chennai, India
Article citation:
Deepikalakshmi B, Mahalakshmi M, Vinod AC,Krithika C, Sudarshan R, Selvamuthukumar SC. CBCT aided diagnosis of impacted fused supernumerary teeth: A case report. J Pharm Biomed Sci. 2015; 05(03):196-201. Available at www.jpbms.info
ABSTRACT: Fusion (synodontia) is defined as a union between the dentin of two or more separately developing teeth. Fusion between two supernumerary teeth is rare. Although combinations of conventional intraoral radiographs and panoramic radiographs are routinely advised in such cases, they fail to provide the critical three dimensional information regarding the position of the impacted teeth and their relation to adjacent anatomical structures. Cone beam computed tomography which has revolutionised dental imaging in the recent past is invaluable for preoperative planning in such developmental disturbances. The purpose of this paper is to present a unique case of fusion of two impacted paramolars, where cone beam computed tomography helped us not only in clinching the diagnosis but also, to accurately determine the morphology and spatial location, and to evolve an appropriate treatment plan.
KEYWORDS: Synodontia; Cone Beam Computed Tomography (CBCT); Supernumerary teeth (ST); Paramolar.
REFERENCES
1.Thiagarajan B, Ramamoorthy G. Dentigerous Cyst From Supernumerary Teeth An Interesting Case Report. Webmed central otorhinolaryngology. 2012;3(11):WMC003801.
2.Rani A K, Metgud S, Yakub SS, et al. Endodontic and esthetic management of maxillary lateral incisor fused to a supernumerary tooth associated with a talon cusp by using spiral computed tomography as a diagnostic aid: a case report. J endod. 2010;36(2):345-49.
3.Shrivastava S, Tijare M, Singh S. Fusion/ double teeth. JIAOMR. 2011;23(3):468-70.
4.Wang XP, Fan J. Molecular genetics of supernumerary tooth formation. Genesis. 2011;49(4):261-77.
5.Dawasaz AA, Sadatullah S, Bokhari SK. Fused Double Supernumerary Premolars of the Mandible: A Rare Case. Case rep Dent. 2012;2012:4.
6.Amarlal D, Muthu M. Supernumerary teeth: Review of literature and decision support system. Indian J Dent Res. 2013;24(1):117-22.
7.Nagaveni N, Umashankara K, Radhika N, Praveen Reddy B, Manjunath S. Maxillary paramolar: report of a case and literature review. Arch Orafac Sci. 2010;5:24-8.
8.Nayak G, Shetty S, Singh I, Pitalia D. Paramolar–A supernumerary molar: A case report and an overview. Dent Res J (Isfahan). 2012; 9(6): 797–803.
9.Pasha Z, Choudhari S, Azhar Rathod A. Bilaterally impacted mandibular supernumerary premolars associated with unusual clinical complications. J pharm Bioallied Sci. 2013;5(2):166-169.
10.Grimanis G, Kyriakides A, Spyropoulos N. A survey on supernumerary molars. Quintessence Int. 1991;22(12):989-995.
11.Garvey MT, Barry HJ, M. B. Supernumerary teeth-an overview of classification, diagnosis and management. J Can Dent.1999;65:612-6.
12.Umut C, Fazil EN, İpek M. Management of A Non-Syndromic Case of Maxillary and Mandibular Supernumerary Teeth: A Clinical Report. The Internet Journal of Dental Science. 2010; 10(1).
13.David Ditto S, Akhila R. Management of Multiple Impacted Supernumerary Teeth in a Non-Syndromic Patient using Cone Beam CT. Dentistry. 2014;4(190):2161-1122.
14.Parolia A, Kundabala M, Dahal M, Mohan M, Thomas MS. Management of supernumerary teeth. J Conserv Dent. 2011;14(3):221224.
Source of funding: None
Competing interest / Conflict of interest: The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
Copyright © 2015 Deepikalakshmi B, Mahalakshmi M, Vinod AC, Krithika C, Sudarshan R, Selvamuthukumar SC. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Research article
Nishu Mittal.1,*, (Pursuing M.D), S K Saxena2.,M.D, Piyush Kumar3.,M.D, AP Sahay4.,M.D, Kailash Mittal5.,M.D, G Kranti Kumar6., (M. Sc Medical)
Affiliation:
1 JR III, Department of Physiology SRMS-IMS Bareilly,
2Professor & Head, Department of Physiology SRMS-IMS Bareilly, UP, India
3Associate Professor, Department. of Radiotherapy SRMS-IMS Bareilly, UP, India
4Professor, Department of Physiology SRMS-IMS Bareilly, UP, India
5Assistant Professor, Department of Radiotherapy RIMS & R Saifai, Etawaha, UP, India
6Lecturer, Department of Physiology SRMS-IMS Bareilly, UP, India
The name of the department(s) and institution(s) to which the work should be attributed:
Department of Physiology & Department of Radiotherapy, SRMS-IMS Bareilly, UP, India
Address reprint requests to
Nishu Mittal,
Department of Physiology,
SRMS-IMS, Bhojipura, Bareilly (U.P)-243202, India
Article citation:
Mittal N, Saxena SK, Kumar P, Sahay AP, Mittal K, Garikapati KK. Assessment of nutritional status In cancer patients using patient generated subjective global assessment. J Pharm Biomed Sci. 2015; 05(03):208-214. Available at www.jpbms.info
ABSTRACT:
Malnutrition is a common problem in cancer patients. The incidence of malnutrition among cancer patients has been estimated 40 - 80% & 30–50% deaths due to Cancer cachexia. Malnutrition can result in increased risk of complications, decreased response & tolerance to treatment. Hence, it becomes important to identify malnutrition at the earliest to improve the treatment outcomes. Patient Generated Subjective Global Assessment (PG-SGA) is an important tool which has been used to identify and grade the nutritional status in cancer patients.
Aim: To assess the Nutritional status of Cancer patients prior to treatment
Material & Methods: 87 naïve cancer patients presenting in Radiotherapy OPD for radical radiotherapy / chemo-radiation were included in this study. Pretreatment nutritional status was assessed using PG-SGA worksheet, Body Mass index (BMI) & 4-site skin fold thickness.
Statistical methods: The data was analyzed using Chi square test & Mcnemar’s test, means, standard deviations and subgroups analyzed using ANOVA. The correlations were made using Pearson’s ‘r’ test.
Results: Mean age of patients was 51 years. Prevalence of malnutrition as assessed by: PG-SGA Score was 62.06 %, SGA Class was 47.13%, BMI was 34.48 % & Body Fat % was 56.32%. SGA class significantly correlated with BMI (p= 0.0068) and Body Fat % (p= 0.0001). PG-SGA Score significantly correlated with SGA class (p= 0.0001), BMI (p=0.00076) and Body Fat % (p = 0.00002).
Conclusion: It was concluded that a substantial number of cancer patients suffered from malnutrition. PG-SGA is a good indicator to assess the nutritional status in cancer patients.
KEYWORDS: Cancer; Malnutrion; PG-SGA; SGA class; BMI; Body Fat%.
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15.Isenring E, Bauer J, Capra S, The scored Patient-generated Subjective Global Assessment (PG-SGA) and its association with quality of life in ambulatory patients receiving radiotherapy. Eur J Clin Nutr. 2003; 57(2): 305–9.
16.Laky B, Janda M, Bauer J et al. Malnutrition among gynaecological cancer patients. Eur J Clin Nutr. 2007; 61: 642–646.
Statement of Originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Source of funding: None
Competing interest / Conflict of interest: The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
Copyright © 2015 Mittal N,Saxena SK,Kumar P,Sahay AP,Mittal K,Garikapati K K. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.