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Original article
M.Johnson Gritto, *V.Nanadagopalan, A. Doss*
Affiliation:
PG & Research Department of Botany, National College (Autonomous), Tiruchirappalli, Tamilnadu – 620 001, India
The name of the department(s) and institution(s) to which the work should be attributed:
Department of Botany, National College (Autonomous), Tiruchirappalli Tamilnadu – 620 001, India
Address reprint requests to
* Dr. V. Nandagopalan.
Associate Professor, PG & Research Department of Botany, National College, Tiruchirappalii- 620 001, Tamilnadu state, India.
Article citation:
Gritto MJ, Nanadagopalan V, Doss A. GC-MS analysis of Hildegardia poplifolia (Roxb.) Schott & Endl – An Endangered Potential Medicinal Plant. J Pharm Biomed Sci. 2015; 05(04):312-316. Available at www.jpbms.info
ABSTRACT:
The present study was carried out to identify the phytocomponents present in the methanolic extract of Hildegardia poplifolia by GC-MS analysis to learn it’s usage by the traditional healers as ‘a plant possessing medicinal properties’. Eighteen compounds were identified. The major constituents are 3, 7, 11, 15-Tetramethyl-2-hexadecen-1-ol (43.96%), Olean-12-ene (11.55%) n-Hexadecanoic acid (10.56%) and 4-Pyrimidinamine, 2, 6-dimethyl- (4.34%). Many of them are used in pharmacy for various uses like antioxidant, anti-diabetic, malaria, anti-inflammatory, anti-cancer and antimicrobial.
KEYWORDS: Gas-chromatography; Ailments; Hildegardia poplifolia; Phyto components.
Statement of Originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
REFERENCES
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Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
Copyright © 2015 Gritto MJ, Nanadagopalan V, Doss A. This is an open access article under the CCBY-NC-SA license (http://creativecommons.org/licenses/by-nc-sa/3.0/). Which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original article
Suprita Gupta1, Archana Jayan2 , Amit Chandra Jha2¥, Narayan Gautam2*
Affiliation:
1Associate Professor, Department of Biochemistry, National Medical College Teaching Hospital, Birgunj, Nepal
2Associate Professor,2¥Lecturer, Department of Biochemistry, Universal College of Medical Sciences, Bhairahawa, Nepal
The name of the department(s) and institution(s) to which the work should be attributed:
1.Department of Biochemistry, National Medical College Teaching Hospital, Birgunj, Nepal
2.Department of Biochemistry, Universal College of Medical Sciences, Bhairahawa, Nepal
Address reprint requests to
* Narayan Gautam.
Associate Professor, Department of Biochemistry, Universal College of Medical Sciences, Bhairahawa, Nepal
Article citation:
Gupta S, Jayan A, Jha AC, Gautam N. Frequency of glycemic control in Type 2 Diabetes Mellitus patients assessed by glycated hemoglobin and estimated average blood glucose. J Pharm Biomed Sci. 2015; 05(04):291-295. Available at www.jpbms.info
ABSTRACT:
Objective: To estimate HbA1c (%) in type 2 Diabetes mellitus (DM) patients to calculate estimated average blood glucose (eAG) and to correlate them with fasting and post prandial blood glucose level.
Materials and methods: HbA1c was estimated in hemolysate by nephelometric method followed by National Glycohemoglobin Standardization Program (NGSP) protocol with MISPA-I2 smart card system in 104 type 2 DM patients. FBG and PPBG were simultaneously determined in serum of patients. The calculation was done by using formula eAG (mg/dl): (28.7*HbA1c)-46.7 given by NSGP/DCCT guideline. The categorization of glycemic control was made as HbA1c ≤5.9% (very good glycemic control), HbA1c between 6.0 and 6.9 % (good glycemic control), HbA1c between 7.0 and 7.9 % (poor glycemic control), HbA1c ≥ 8% (bad glycemic control).
Results: The age-wise categorization of type 2 DM shows maximum frequency of patients of 21 (20.19 %) comprising 10 (9.61 %) male and 11(10.57 %) female respectively in age group 41-60 whose HbA1c and eAG were (7.6 ± 2.9 %) and eAG (172.66 ± 81.79 mg/dl) respectively. The statistically significant correlation was observed between HbA1c/eAG with FBG and PPBG (p<0.001).
Conclusion: The high frequency of patients in categories >8.0 % HbA1c and increased eAG signifies the bad glycemic control and project to the complication associated with DM later in life.
KEYWORDS: HbA1c; estimated average glucose; glycemic control; Type 2 DM.
Statement of Originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
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Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
Copyright © 2015 Gupta S, Jayan A, Jha AC, Gautam N. This is an open access article under the CCBY-NC-SA license (http://creativecommons.org/licenses/by-nc-sa/3.0/). Which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Short communication
Senthilkumar Rajagopal*, Supraj Raja Sangam, Shubham Singh
Affiliation:
Department of Zoology, Nizam College, Hyderabad, Telangana, India
The name of the department(s) and institution(s) to which the work should be attributed:
Department of Zoology, Nizam College, Hyderabad, Telangana, India
Address reprint requests to
* Dr.R.Senthilkumar, Ph.D.,
DBT-Ramalingaswami Re-entry Fellow,
Dept of Zoology, Nizam College, Hyderabad, Telangana, India
Article citation:
Rajagopal S, Sangam SR, Singh S. Contribution of Protein Kinase C (PKC) in the modulation of Voltage gated Calcium Channels. J Pharm Biomed Sci. 2015;05(04):351-354. Available at www.jpbms.info
ABSTRACT:
High voltage-gated calcium (CaV) channels are the major source for Ca2+ influx that underlies Ca2+ -dependent response in excitable cells. Protein kinase C (PKC) is families of protein kinases enzymes that are play important roles in several signal transduction cascades. Ca2+, CaV channels and PKC are involved in the processes of pain, insulin secretion, glucose homeostasis, smooth muscle physiology, response to neuro-chemicals, receptor sensitization, in modulating membrane structure events, in mediating immune response, in regulating cell growth, and in learning and memory. The identification of the roles of these proteins will provide us significant knowledge for the understanding of the complexity of the ion channel physiology and regulation of many diseases. In this short communications, we discuss the contribution of PKC in the modulation of calcium channels in Xenopus oocytes model.
KEYWORDS: Acetyl-β-methylcholine; insulin; pain; phorbol-12-myristate-13-acetate;phosphorylation sites; Xenopus oocytes.
Statement of Originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
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Source of support: This work was supported by Department of Biotechnology, Ministry of Science & Technology, and Government of India to R.S.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
Copyright © 2015 Rajagopal S, Sangam SR, Singh S. This is an open access article under the CCBY-NC-SA license (http://creativecommons.org/licenses/by-nc-sa/3.0/). Which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original article
Deepti Sureka Mummidi1,*,Dharmendra Dugar1,±, Ranjit K Mishra1,¥,
Jatasankar Mohapatra1,±, Tim Houghton T1
Affiliation:
1P.G Student, 1±Professor, 1¥Professor and HOD Department of General surgery, Hi-Tech Medical College and Hospital, Bhubaneswar, Odisha, India
The name of the department(s) and institution(s) to which the work should be attributed:
Department of General surgery, Hi-Tech Medical College and Hospital, Bhubaneswar, Odisha, India
Address reprint requests to
* Dr. Deepti Sureka Mummidi.
P.G Student, Department of General surgery, Hi-Tech Medical College and Hospital, Bhubaneswar, Odisha, India
Address: Flat no A108, Gatikrushna lagoon, near megheswar temple, Tankapani road, Bhubaneswar, odisha, India 751018.
Article citation:
Mummidi DS,Dugar D,Mishra RK, Mohapatra JS, Houghton T. Clinicopathological study: management Of diabetic foot and its Complications. J Pharm Biomed Sci. 2015; 05(04):308-311. Available at www.jpbms.info
ABSTRACT:
Diabetes is a lifelong problem, and the incidence of diabetic foot complications increases with age and duration of the disease. Ulceration, infection, gangrene, and amputation are significant complications of the disease. Diabetic foot infections are frequently polymicrobial in nature. Hyperglycemia, impaired immunologic responses, neuropathy, and peripheral arterial disease are the major predisposing factors leading to limb-threatening diabetic foot infections.
Objectives of the study: To understand the pathology of diabetic foot and relative distribution of this condition according to age, sex, among diabetic patients. To study the benefit and outcome of the different treatment modalities for diabetic foot
Methods: This study was conducted comprising of 100 patients of diabetic foot in the department of general surgery at Hitech medical college and hospital, Bhubaneswar, Odisha, during the period of Jan 2013 to Jun 2014.
Results: Commonest presenting lesion was ulcers (44%), followed by gangrene (24%) and cellulitis (20%). Commonest site of the lesion was dorsum of the foot (32%), followed by fore foot (28%), and toes (22%). Trivial trauma is the initiating factor in more than half of the cases. More than half of the patients 82% had infection. Most common microorganism grown from culture was staphylococcus aureus (30%), 28(28%) patients were treated with wound debridement, 18(18%) patients underwent major amputation. Prognosis was good in 72(72%) patients. 2(2%) patient died due to septicemia.
Conclusion: Diabetic patients at risk for foot lesions must be educated about risk factors. The multidisciplinary team approach to diabetic foot disorders has been demonstrated as the optimal method to achieve favorable rates of limb salvage in the high-risk diabetic patient. Infection in a diabetic foot is potentially limb-threatening and always requires urgent diagnostic and therapeutic attentions.
KEYWORDS: Diabetes; foot ulcers; neuropathy; ischemia.
Statement of Originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
REFERENCES
1.Reiber GE. Epidemiology of foot ulcers and amputation in the diabetic foot. Bowker JH, Pfeifer MA, eds. The diabetic foot, 6th ed. st. Louis, Mo:Mosby Inc;2001:13-32.
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Source of support: None
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
Copyright © 2015 Mummidi DS,Dugar D,Mishra RK, Mohapatra JS, Houghton T. This is an open access article under the CCBY-NC-SA license (http://creativecommons.org/licenses/by-nc-sa/3.0/). Which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original article
Nirmalya Nirbisank1,*, Ranjit Kumar Mishra1,¥
Affiliation:
1P.G Student,1¥Professor and HOD Department of General surgery, Hi-Tech Medical College and Hospital, Bhubaneswar, Odisha, India
The name of the department(s) and institution(s) to which the work should be attributed:
Department of General surgery, Hi-Tech Medical College and Hospital, Bhubaneswar, Odisha, India
Address reprint requests to
* Dr Nirmalya Nirbisank.
3rd, P.G Student, Department of General surgery, Hi-Tech Medical College and Hospital, Bhubaneswar, Odisha, India
Article citation:
Nirbisank N, Mishra RK. Amylase creatinine clearance ratio in post-operative patients for evaluation of acute pancreatitis. J Pharm Biomed Sci. 2015; 05(04):296-299. Available at www.jpbms.info
ABSTRACT:
Background: Post operative pancreatitis is a well known complication of biliary tract operations,particularly following supraduodenal exploration of the common bile duct and transduodenal sphincterotomy.Although this event occurs in a relatively small number of patients following these procedures,it is an event that should be avoided whenever possible.It is found that the diagnostic value of amylase measurements may be enhanced if amylase excretion is related to creatinine excretion.
Material and Methods: It is a study conducted on the amylase creatinine clearance ratio in post operative patients for evaluation of pancreatitis..The data collected for our study included patients from Hitech medical college and hospitals, Bhubaneswar,Odisha, India during the period from August 2012 to November 2014.
Results: The study was conducted on sixty cases who were posted for surgery for at Hitech medical college and hospital Bhubaneshwar,Odisha,India. They were divided in to two groups of thirty cases each depending on the surgeries involved.
Conclusion: In this present study we assess the changes in the level of amylase creatinine clearance ratio in the post operative period and its value in the diagnosis of post-operative pancreatitis.
KEYWORDS: Pancreatitis; Serum amylase; Amylase creatinine clearance ratio.
Statement of Originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
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Source of support: None
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
Copyright © 2015 Nirbisank N, Mishra RK. This is an open access article under the CCBY-NC-SA license (http://creativecommons.org/licenses/by-nc-sa/3.0/). which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.