DocumentsDate added
Original article
Oluwatosin K. Shittu1, Bashir Lawal1,*, Asmau N. Abubakar1, Eustace B. Berinyuy2, ,Busari B. Musa3, Ibrahim A Olalekan4.
Affiliation:
1Tropical Disease Research Unit, Department of Biochemistry, Federal University of Technology, P.M.B.65, Minna, Nigeria
2Faculty of medicine and Biomedical Science, University of Yaounde 1, Cameroon
3Centre for Genetic Engineering and Biotechnology, Global Institute for Bioexploration Unit, Federal University of Technology Minna, Nigeria.
4Forestry Technology Department Federal College of Wild Life Management, New Bussa, Niger State, Nigeria
The name of the department(s) and institution(s) to which the work should be attributed:
1.Tropical Disease Research Unit, Department of Biochemistry, Federal University of Technology, P.M.B.65, Minna, Nigeria
2.Faculty of medicine and Biomedical Science, University of Yaounde 1, Cameroon
3. Centre for Genetic Engineering and Biotechnology, Global Institute for Bioexploration Unit, Federal University of Technology Minna, Nigeria.
4. Forestry Technology Department Federal College of Wild Life Management, New Bussa, Niger State, Nigeria
Address reprint requests to
* Bashir Lawal.
Department of Biochemistry, Tropical Disease Research Unit, Federal University of Technology, P.M.B. 65, Minna, Nigeria.
Phone no: +234 -8165112378
Article citation: Shittu OK, Lawal B, Abubakar AN, Berinyuy BE, Busari MB, Ibrahim AO. Toxicological implications of methanol extract from Nigerian Bee propolis on some selected rat tissues. J Pharm Biomed Sci. 2015; 05(07):524-531. Available at www.jpbms.info
ABSTRACT: Objectives: The present study investigates the effects of Nigerian bee propolis on some biochemical indices in some selected rat tissues. Methods: A total of Fifteen wistar rats were grouped into 3(A-C) of 5 rats each. Group A rats serve as control groups and received 0.5ml of DMSO, while groups B and C received 300 and 600 ml/kg of methanol extract of honey bee propolis respectively, for 21 days through oral route.
Results: The extract significantly increased (p<0.05) the Spleen and small intestine ALT activities, kidney and small intestine AST activities, kidney ALP activities as well as the level of total protein in Liver and spleen of bee propolis treated rats. In contrast, the Liver and spleen AST activities, and liver ALP activities decrease significantly (p<0.05) in bee propolis treated rats when compared with their corresponding controls. However, the spleen and small intestine ALP activities, level of kidney and small intestine total protein as well as ALT activities in the kidney of bee propolis treated rats compared well (p>0.05) with the normal value at the extract doses studied. The computed liver, kidney, and small intestine body weight ratios of rats treated with the extract does not differ(p>0.05) with those of the control rats, however, increase in spleen/body weight in propolis treated rats than the control group was observe.
Conclusion: The chronic administration of methanol extracts of bee propolis altered the normal values of some biochemical parameters in rat organs. Clinical application of the bee propolis should therefore be carefully controlled as it chronic administration may be relatively unsafe for the integrity of organs.
KEYWORDS: Propolis; Liver; Kidney; Spleen; Small intestine; Biomarker enzyme; Total proteins.
REFERENCES
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Statement of Originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Source of funding: None
Competing interest / Conflict of interest: The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
Majority of the information gathered are from media sources which don’t reflect the author’s own opinion.
Copyright © 2015 Shittu OK, Lawal B, Abubakar AN, Berinyuy BE, Busari MB, Ibrahim AO. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Case report and review of literature
Jigar M Dhuvad1,*,Rajesh A Kshirsagar2,Mukesh M Dhuvad3
Affiliation:
1Assistant Professor, Government Dental College and Hospital, Ahmedabad, India.
2Professor and Head, Bharati Vidyapeeth Dental College and Hospital, Pune, India
3Private practiconer, Ahmedabad, India
The name of the department(s) and institution(s) to which the work should be attributed:
Department of Oral and Maxillofacial Surgery, Bharati Vidyapeeth Dental College and Hospital, Pune, India
Address reprint requests to
* Dr Jigar M Dhuvad (MDS)
D-34; Ishan-1; Behind Seema Hall, Satellite, Ahmedabad, India or at drjigardhuvad1981@gmail.com
Article citation: Dhuvad JM, Kshirsagar RA, Dhuvad MM. Mucormycosis: An opportunistic fungal infection in uncontrolled diabetic patients: Experience of two cases and a review of literature. J Pharm Biomed Sci. 2015; 05(07):583-588. Available at www.jpbms.info
ABSTRACT: Mucormycosis, also known as zygomycosis, is an opportunistic fulminant fungal infection, which mainly affects the immunocompromised patients. The infection begins in the nose and paranasal sinuses due to inhalation of fungal spores. It has six predominant clinical forms: rhinocerebral, central nervous system, pulmonary, cutaneous, gastrointestinal, disseminated, and uncommon (i.e., heart, bone, kidney, mediastinum, bladder, and oral). Although oral involvement of this condition has been reported relatively frequently in the literature, we report two cases of mucormycosis in an uncontrolled diabetic patient. Because of its rapid progression and high mortality, early diagnosis of this potentially fatal fungal infection along with aggressive treatment offers the only chance to increase the survival rates. The purpose of this article is to report our clinical experience with two cases of mucormycosis of the maxilla in relation with uncontrolled diabetes mellitus and a review of the literature in relation to various types of mucormycosis.
KEYWORDS: Central nervous system; fungal infections; maxilla; mucormycosis.
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Statement of Originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Source of funding: None
Competing interest / Conflict of interest: The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
Copyright © 2015 Dhuvad JM, Kshirsagar RA, Dhuvad MM. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Review article
Divya Jaggi¥*, Anjani Pathak¥, Jaya Dixit¥, Indira Chaturvedi¥, Kopal Goel±
Affiliation:
¥Department of Periodontology, ±Department of Prosthodontics, Faculty of Dental Sciences, King George’s Medical University, Lucknow-226003, India
The name of the department(s) and institution(s) to which the work should be attributed:
Department of Periodontology, Faculty of Dental Sciences, King George’s Medical University, Lucknow-226003, India
Address reprint requests to
* Dr. Divya Jaggi.
Senior Resident, Department of Periodontology, Faculty of Dental Sciences, King George’s Medical University, Lucknow-226003, India
Article citation: Pathak A, Jaggi D, Dixit J, Chaturvedi I, Yadav K. Pharmacologic agents in periodontics: A review. J Pharm Biomed Sci. 2015;05(07):609-620. Available at www.jpbms.info
ABSTRACT: The fundamental aspect of the treatment is that the clinician should constantly update his knowledge on the drugs being administered during the course of treatment and their interactions. This article focuces on the current pharmacological agents being used in the management of periodontal conditions. All drug sensitivities and allergies should be reviewed prior to incorporating pharmacological agents into a patient’s treatment regimen. Recent advances in technology have led to a constant drive to develop novel strategies for the treatment of periodontal diseases. The future is promising in the areas of vaccines but more research is needed.
KEYWORDS: Pharmacology; Therapeutics; Periodontics.
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Source of funding: None
Competing interest / Conflict of interest: The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
Majority of the information gathered are from media sources which don’t reflect the author’s own opinion.
Copyright © 2015 Pathak A, Jaggi D, Dixit J, Chaturvedi I, Yadav K. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original article
*Shradha Sethi., MDS,† Tarun Sethi., MDS,‡ Kala Bhushan., MDS,** Pinal Kabrawala., MDS,†† Pradeep Kumar., MDS,‡‡ Nitin Sharma., MDS‡‡
Affiliation:
*Department of Periodontology, Rajasthan Dental College and Hospital, Jaipur, India group of Hospitals, Bikaner, Rajasthan, India
†Department of Pedodontics, Rajasthan Dental College and Hospital, Jaipur, India
‡ Department of Periodontology, College of Dental Sciences, Davangere, India
**Department of Pedodontics, Ahmedabad Dental College, Ahmedabad, India
††Department of Periodontology, Rajasthan Dental College and Hospital, Jaipur, India
‡‡Department of Pedodontics, Rajasthan Dental College and Hospital, Jaipur, India
The name of the department(s) and institution(s) to which the work should be attributed:
College of Dental Sciences, Davangere, India
Address reprint requests to
Dr. Shradha Sethi.
Department Of Periodontology,
Rajasthan Dental College and Hospital,Jaipur, India
Article citation:
Sethi S, Sethi T, Bhusan K, Kabrawala P, Kumar P, Sharma N. Assessment of the efficacy of Aloe vera gel in chronic periodontitis patients: A clinical and microbiological study. J Pharm Biomed Sci. 2015; 05(07):598-608. Available at www.jpbms.info
ABSTRACT:
Background & Objectives: In recent years, efforts have been made to test herbal remedies in treating inflammation and infections. Here an attempt is made to assess the clinical benefits of pure Aloe vera gel (98%) used as an adjunct to non surgical periodontal therapy.
Materials and Methods: 10 patients each with at least 3 sites with probing depth 5-7 mm in different quadrants were included. A split mouth design was used and sites in each patient were randomly allocated into experimental sites A (Intrapocket application of Aloe vera gel) & B (gel application along with SRP) and control site C (only SRP). Plaque index, gingival index, gingival bleeding index, probing pocket depth and relative attachment level were assessed at baseline, 3 weeks and 6 weeks. Subgingival plaque sample was collected to assess Streptococci and Porphyromonas gingivalis by anaerobic culture method.
Results: The results showed on intra-group analysis significant reduction (p<0.01) of clinical parameters (PI, GI, GBI, PPD & RAL) and periodontal pathogens in all the treatment groups whereas on inter-group analysis, significant difference was seen between aloe monotherapy and other two groups which had similar outcomes.
Interpretation and Conclusion: In present study treatment with aloe vera gel as an adjunct to SRP showed almost similar results to cases treated with SRP alone without any statistically significant differences. The anti-inflammatory and antimicrobial effects of aloe vera, suggests it as a promising agent to be used for treatment of periodontal diseases. Future studies including larger sample sizes and sustained release formulation of the gel are certainly encouraged to further explore the potential benefits.
KEYWORDS: Aloe vera; chronic periodontitis; scaling and root planing; local drug delivery; periodontopathogens; herbal; anti-inflammatory; antimicrobial.
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Statement of Originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Source of funding: None
Competing interest / Conflict of interest: The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
Copyright © 2015 Sethi S,Sethi T,Bhusan K,Kabrawala P,Kumar P,Sharma N. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original article
Jyoti Bala*,Kumar Saurabh,Veena Singh Ghalaut, Yuthika Aggrawal
Affiliation:
*Department of Biochemistry, Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India
The name of the department(s) and institution(s) to which the work should be attributed:
Department of Biochemistry, Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India
Address reprint requests to
* Dr. Jyoti Bala,
D-2, New Bharat, Nagar, Bhiwani, Haryana,India
Article citation: Bala J, Saurabh K, Ghalaut VS, Aggrawal Y. Study the levels of folic acid, vitamin B12 and ferritin in thalassemia. J Pharm Biomed Sci. 2015; 05(07):539-541. Available at www.jpbms.info
ABSTRACT: Objective: To estimate the levels of folic acid, vitamin B12 and ferritin in thalassemic children.
Material and Methods: This study was carried out in the Department of Biochemistry in PGIMS, Rohtak. Thirty children with the confirmed diagnosis of thalassemia were enrolled in the study group and thirty healthy age and sex matched children were included in the control group. Estimation of serum ferritin, folic acid and vitamin B12 were done by ADVIA Centaur CP autoanalyzer by chemiluminescence immunoassay.
Results: Study group showed a decrease in serum folic acid and vitamin B12 levels with mean value of 8.91 ±1.04 ng/mL and 241.33± 29.28 pg/mL respectively as compared to control group was 12.23±1.31 ng/mL and 419.63±58.47 pg/mL (p<0.001) whereas increased concentration of ferritin with mean value of 3466.75± 2028.96 ng/mL in study group as compared to control group was 176.70±11.63 and was statistically highly significant (p<0.001).
Conclusion: The present study found a significant decrease of vitamin B12, folic acid and increased ferritin in children with thalassemia. Biochemical screening of these parameters is of paramount importance in thalassemia patients in paediatric age group. Also, there is an absolute need for further studies to understand the mechanism of relationship between serum ferritin, Vitamin B12 and folic acid in these patients.
KEYWORDS: Thalassemia; Ferritin; vitamin B12; Folic acid.
Statement of Originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
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Source of funding: None
Competing interest / Conflict of interest: The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
Majority of the information gathered are from media sources which don’t reflect the author’s own opinion.
Copyright © 2015 Bala J,Saurabh K,,Ghalaut VS,Aggrawal Y. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.