Property | Value |
Name | Quantum Dots In Medical Science |
Description | Review article
Rahul Kumar Mishr1,*, Jitender Dhillon2, Rajesh Pandey3, K. S. Sodhi3, Jasbir Singh3
Affiliation:- 1 MSc MLT (Intern), 2MD Student, 3Professor (MD) Department of Biochemistry, MMIMSR, Mullana, Ambala, Haryana, India
The name of the department(s) and institution(s) to which the work should be attributed: Department of Biochemistry, MMIMSR, Mullana, Ambala, Haryana, India
Address reprint requests to Rahul Kumar Mishr. MSc MLT (Intern), Department of Biochemistry, MMIMSR, Mullana, Ambala, Haryana, India., India
Article citation: Mishr RK, Dhillon J, Pandey R, Sodhi KS, Singh J. Quantum Dots In Medical Science. J Pharm Biomed Sci. 2014; 04(12):1042-1049. Available at www.jpbms.info
ABSTRACT: Quantum dots (QDs) are tiny semiconductor crystals of size 1-10 nanometres made up of compounds from group II to VI and III to V. The exceptional photophysical properties of QDs, particularly photostability and emission as a function of size, make them superior to organic dyes for biological applications: microscopy and multiplexed histology, flow cytometry, drug delivery, photodynamic therapy, clinical imaging, real time detection of intracellular events etc. Thus, QDs and their alliance with other aspects of nanotechnology have opened new possibilities for advanced molecular and cellular imaging as well as for ultrasensitive bioassays, diagnostics and therapeutics. However, high-quality and well-controlled trials specifically addressing certain inherent pitfalls of QDs will need to be undertaken before these can be considered for human use.
KEYWORDS: Quantum dots; nanotechnology; medicine; diagnosis; therapy.
REFERENCES 1.Gao X, Dave SR. Quantum dots for cancer molecular imaging. In: Bioapplication of nanoparticles, Chan WCW editor. Landes Bioscience and Springer science + Business Media, 2007, Chapter 5, p. 57-73. 2.Maiti A, Bhattacharyya S. Review: Quantum dots and application in medical science. IJCCE. 2013; 3(2): 37-42. 3.Shukla SK. Recent developments in biomedical applications of quantum dots. Adv Mater Rev. 2014; 1(1): 2-12. 4.Nie S, Xing Y, Kim GJ, Simons JW. Nanotechnology applications in cancer. Ann Rev Biomed Eng. 2007; 9: 257– 288. 5.Xing Y, Rao J. Quantum dot bioconjugates for in vitro diagnostics & in vivo imaging. Cancer Biomarkers. 2008; 4: 307-319. 6.Wang F, Tan WB, Zhang Y, Fan XP, Wang MQ. Luminescent nanomaterials for biological labelling. Nanotechnology. 2006; 17: R1–R13. 7.Peng J, Gao W, Gupta BK, Liu Z, Romero-Aburto R, Ge LH, et al. Graphene quantum dots derived from carbon fibers. Nano Lett. 2012; 12: 844-849. 8.Han MY, Gao XH, Su JZ, Nie S. Quantum-dot-tagged microbeads for multiplexed optical coding of biomolecules. Nat Biotechnol. 2001; 19: 631–5. 9.Jamieson T, Bakhshi R, Petrova D, Pocock R, Imani M, Seifalian AM. Biomaterials. 2007; 28: 4717-4732. 10.Weng JF, Ren JC. Luminescent quantum dots: a very attractive and promising tool in biomedicine. Curr Med Chem. 2006; 13: 897–909. 11.Medintz IL, Uyeda HT, Goldman ER, Mattoussi H. Quantum dot bioconjugates for imaging, labelling and sensing. Nat Mater. 2005; 4: 435–46. 12.Derfus AM, Chan WCW, Bhatia SN. Probing the cytotoxicity of semiconductor quantum dots. Nano Lett. 2004; 4: 11–8. 13.Chan WH, Shiao NH, Lu PZ. CdSe quantum dots induce apoptosis in human neuroblastoma cells via mitochondrial-dependent pathways and inhibition of survival signals. Toxicol Lett. 2006; 167:191–200. 14.Hoshino A, Fujioka K, Oku T, Suga M, Sasaki YF, Ohta T, et al. Physicochemical properties and cellular toxicity of anocrystal quantum dots depend on their surface modification. Nano Lett. 2004; 4: 2163–9. 15.Ho CL, Kurman RJ, Wang TL, Shih IM. Mutations of BRAF and KRAS precede the development of ovarian serous borderline tumors. Modern Pathol. 2005; 18: 186A. 16.Hanaki K, Momo A, Oku T, Komoto A, Maenosono S, Yamaguchi Y, et al. Semiconductor quantum dot/albumin complex is a long-life and highly photostable endosome marker. Biochem Biophys Res Commun. 2003; 302: 496–501. 17.Hoshino A, Fujioka K, Oku T, Nakamura S, Suga M, Yamaguchi Y, et al. Quantum dots targeted to the assigned organelle in living cells. Microbiol Immunol. 2004; 48: 985–94. 18.So MK, Xu CJ, Loening AM, Gambhir SS, Rao JH. Self illuminating quantum dot conjugates for in vivo imaging. Nat Biotechnol. 2006; 24: 339–43. 19.Giepmans BNG, Deerinck TJ, Smarr BL, Jones YZ, Ellisman MH. Correlated light and electron microscopic imaging of multiple endogenous proteins using quantum dots. Nat Methods. 2005; 2: 743–9. 20.Choi AO, Cho SJ, Desbarats J, Lovric J, Maysinger D. Quantum dot-induced cell death involves Fas upregulation and lipid peroxidation in human neuroblastoma cells. J Nanobiotechnol. 2007; 5: 1–4. 21.Madani SY, Shabani F, Dwek MV, Seifalian AM. Conjugation of quantum dots on carbon nanotubes for medical diagnosis and treatment. Int J Nanomed. 2013; 8: 941-950. 22.Jiang W, Papa E, Fischer H, Mardyani S, Chan WC. Semiconductor quantum dots as contrast agents for whole animal imaging. Trends Biotechnol. 2004; 22(12): 607–609. 23.Banerjee S, Wong SS. In situ quantum dot growth on multiwalled carbon nanotubes. J Am Chem Soc. 2003; 125(34): 10342–10350. 24.Muthunayagam V, Ramachandran V, Annie J, Francis BF, Annie A. Effective cellular internalization of silica-coated CdSe quantum dots for high contrast cancer imaging and labelling applications. Cancer Nanotechnol. 2014; 5(1): 1-12. 25.Lidke DS, Nagy P, Heintzmann R, Jovin DJA, Post JN, Grecco HE, et al. Quantum dot ligands provide new insights into erbB/HER receptor-mediated signal transduction. Nat Biotechnol. 2004; 22(2):198–203. 26.Bonasio R, Carman CV, Kim E, Sage PT, Love KR, Mempel TR, et al. Specific and covalent labeling of a membrane protein with organic fluorochromes and quantum dots. Proc Natl Acad Sci USA. 2007; 104(37): 14753-14758. 27.Shao L, Gao Y, Yan F. Semiconductor quantum dots for biomedicial applications. Sensors. 2011; 11: 11736-11751.
Source of support: None
Competing interest / Conflict of interest The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Copyright © 2014 Mishr RK ,Dhillon J, Pandey R, Sodhi KS,Singh J. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Filename | Mishr RK(1042-1049).pdf |
Filesize | 982.3 kB |
Filetype | pdf (Mime Type: application/pdf) |
Creator | admin |
Created On: | 12/05/2014 05:26 |
Viewers | Everybody |
Maintained by | Editor |
Hits | 2526 Hits |
Last updated on | 12/05/2014 05:30 |
Homepage | |
CRC Checksum | |
MD5 Checksum |