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Name | The Haematological Effects of Chronic Toxicity with Cassia singueana Leaf Extract in Rats |
Description | Original research article:- *Ode, Okwoche J.1, and Nwaehujor, Chinaka O.2
1.Ph.D, Department of Veterinary pharmacology and Toxicology, University of Abuja, PMB 117 Abuja, Nigeria. 2.M.Sc, Department of Biochemistry, University of Nigeria, Nsukka, Enugu State.
Abstract:- The methanol extract of Cassia singueana leaves was reported to have exhibited potent anti-ulcer effects when it significantly decreased stomach hydrochloric acid production and reduced gastric emptying in test rats. In most cases, ulcer patients require prolonged (4-8 weeks) therapy with anti-ulcer drugs for successful treatment. The long-term effects of C. singueana leaf extract on haematological parameters were investigated in rats. The extract was prepared by cold marceration using 80% methanol, it was then filtered and concentrated. Four groups (A-D) of albino wistar rats were subjected to chronic exposure by feeding the animal groups with normal diet or 0.25 g extract /kg feed, 0.5 g extract/kg feed and 1.0 g extract/kg feed respectively for 12 weeks. Haematological parameters were assessed on days 28, 56 and 84 using standard procedures. The data collected were statistically analyzed using one–way Analysis of variance (ANOVA) and LSD post hoc test. The results revealed that Cassia singueana extract (CSE) had no significant (P=0.05) effect on red blood cell (RBC) count, white blood cell (WBC) count, packed cell volume (PCV), haemoglobin concentration (Hb), mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH) and mean corpuscular haemoglobin concentration (MCHC) of control rats relative to the separate rat groups that were given varying doses of CSE in the diet. The results of this study suggest that C. singueana extract does not possess haemotoxic activities that could limit its therapeutic use as an anti-ulcer agent. Keyword:- Bone marrow; Cassia singueana; chronic toxicity; Erythrocyte; Haematological parameters. |
Filename | Ode Okwoche J et al. -2.pdf |
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Created On: | 07/17/2011 00:00 |
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Last updated on | 08/13/2011 18:10 |
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