Property | Value |
Name | The Effects of Methanolic and Aqueous Extract of Evolvulus Alsinoides on Clinical Isolates |
Description | Original research article:- *M.P.Saraswathy1, U.M. Dhanalekshmi2
1.M.D Microbiology, Assistant Professor of Microbiology, Melmaruvathur Adiparasakthi Institute of Medical sciences & RI, Melmaruvathur,Tamilnadu- 603319 ,India. 2.M .Pharm PhD, SRF, Dept of Bio-organic, CLRI, Chennai,Tamilnadu, India.
Abstract:- Plants are among the most important and common sources of potentially valuable new drugs. Use of herbal products as antimicrobial agents may provide the best alternative to the wide and injudicious use of synthetic antibiotics. The aim of this study was to determine the level of antimicrobial activity of aqueous and methanolic extract of Evolvulus alsinoides (EA) towards 9 bacterial isolates and 5 fungal isolates. The study was conducted at department of Microbiology, Melmaruvathur AdhiParasakthi Institute of Medical Sciences and Research. The assays were performed using disc diffusion method and MIC was calculated by agar dilution method. Ciprofloxacin was used as a standard reference drug. In our study, aqueous extract displayed strong antimicrobial activity against Staphylococcus aureus, S.epidermidis, Klebsiella pneumoniae and Vibrio cholera. The MIC value 133µg/ml of methanolic extract was inhibitory to most of the gram negative organisms tested, except E.coli. The aqueous extract was effective against all the fungal isolates tested at MIC of ≥166 µg/ml. The identified phytochemical compounds viz., flavonoids and alkaloids may be responsible for the antimicrobial activity of EA. The study shows that plant extract has wide antimicrobial as well as antifungal activity. Therefore, it supports the traditional use of the plant in the treatment of infectious diseases like Enteric fever, Cholera and fungal skin diseases caused by candida and dermatophyte.
Key words:- Aqueous extract, Antimicrobial activity, Antifungal activity, Evolvulus alsinoides, Methanolic extract, MIC. |
Filename | Saraswathy M. P et al..pdf |
Filesize | 224.29 kB |
Filetype | pdf (Mime Type: application/pdf) |
Creator | admin |
Created On: | 08/16/2011 00:00 |
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Maintained by | Editor |
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Last updated on | 09/05/2011 13:23 |
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