Property | Value |
Name | “Epidemiological & clinical features among patients hospitalized in Saurashtra region with 2009 pandemic influenza A (H1N1), September 2009 to February 2011 (two waves)” |
Description | Original research article:- *Rajesh K Chudasama1, Umed V Patel2, Pramod B Verma3, Priyanka K Patel4, Ravikant R Patel5, Chikitsa D Amin5. 1.M.D. (Community Medicine), Associate Professor, Community Medicine Department, M P Shah Medical College, Jamnagar, India. 2.M.D. (Community Medicine), Associate Professor, Community Medicine Department, P D U Medical College, Rajkot, India. 3.M.D. (Community Medicine), Professor & Head, Community Medicine Department, P D U Medical College, Rajkot, India. 4.Tutor (Microbiology), Microbiology Department, M P Shah Medical College, Jamnagar, India. 5.M.D. (Community Medicine), Assistant Professor, Community Medicine Department, P D U Medical College, Rajkot, India.
Abstract:- Background: The first case of 2009 pandemic influenza A (H1N1) virus infection in India was reported in May, 2009 and in Saurashtra region in August, 2009. We describe the clinical & epidemiological characteristics of patients who were hospitalized with 2009 influenza A (H1N1) infection in Saurashtra region. Materials and Methods: From September, 2009 to February, 2011, total 511 persons infected with 2009 influenza A (H1N1) virus who were admitted in different hospitals in Rajkot city. Real-time reverse-transcriptase-polymerase-chain-reaction (RT-PCR) testing was used to confirm infection; the clinical & epidemiological features of the disease were closely monitored. Results: Of 511 patients, median age was 28 years, and 50.5% were males. Only 0.2% patients had recent travel history to infected region. Median time of five days was observed from onset of illness to influenza A (H1N1) diagnosis, while median time of six days reported for hospital stay. All admitted patients received oseltamivir drug, but only 14.9% received it within two days of onset of illness. One fourth of admitted patients were expired. The most common symptoms were cough (98.0%), fever (94.9%), sore throat and shortness of breathing, and coexisting conditions including hypertension (10.4%), diabetes mellitus (9.4%), chronic pulmonary diseases (4.3%) and pregnancy (4.3%) (P<0.05). Pneumonia was reported in 91% patients with chest radiography. Conclusion: We have demonstrated that infection-related illness affects both children and adults with survival of 75.1% patients. The median time from onset of illness to virus detection with use of real-time RT-PCR is five days. Pregnancy is found as a significant (P<0.05) risk factor for severe disease.
Key Words:- Epidemiologic information, H1N1 subtype, influenza A virus, reverse transcriptase polymerase chain reaction. |
Filename | Chudasama Rajesh K et.al..doc.pdf |
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Creator | admin |
Created On: | 09/16/2011 00:00 |
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Last updated on | 10/05/2011 05:52 |
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