Property | Value |
Name | Reduced susceptibility of Vancomycin in Methicillin Resistant Staphylococcus aureus (MRSA) in and around Visakhapatnam, Andhra Pradesh |
Description | Research article:- *DR.Bandaru Narasinga Rao., MD., Ph.D1., DR.T.Prabhakar.,M.Sc.,Ph.D2 1.Professor & Head, Department of Microbiology, Rajivgandhi Institute of Medical Sciences (RIMS), Srikakulam -532 001 (AP), India. 2.Professor & Head, Division of Biotechnology, University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam – 530 003 (AP), India. Abstract:- Purpose: Increasing minimum inhibitory concentration of an antimicrobial for a bacterium is the marker of future resistance of the organism to that antibiotic. Vancomycin is the drug of choice for the infections caused by Methicillin Resistant Staphylococcus aureus (MRSA) and often used empirically for the patients in critical-care settings with infections like severe sepsis, pneumonias and meningitis in India. We report the occurrence of Vancomycin Intermediate Resistant Staphylococcus aureus (VISA) in and around Visakhapatnam, Andhra Pradesh. Methods: A total of 7840 clinical specimens were collected from different patients and subjected to MRSA screening using conventional microbiological methods.The detection of VISA was done by Agar dilution method and E-Test. Results: All the isolates of MRSA as well as MSSA were sensitive to Vancomycin by Kirby-Bauer’s disc diffusion method. As per CLSI standards, 6.79% of our isolates were Vancomycin Intermediate Resistant Staphylococcus aureus (VISA) by agar dilution method among 162 MRSA. The same were confirmed by E-Test (Epsilometer Test) which was the gold standard for determining the decreased susceptibility of Vancomycin in Staphylococcus aureus.
Keywords:- Methicillin Resistant Staphylococcus aureus (MRSA), Antimicrobial Sensitivity, Vancomycin,Vancomycin Intermediate Staphylococcus aureus (VISA),Vancomycin Resistant Staphylococcus aureus (VRSA). |
Filename | Bandaru Narasinga Rao et.al.-1.pdf |
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Created On: | 09/16/2011 00:00 |
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Last updated on | 10/05/2011 07:14 |
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