Property | Value |
Name | Study of defect in calcium Homeostasis in Asthmatic children |
Description | Research article:- *Nagdeote A.N.1, Dange N. S.2, Deshpande K. A.3 and Pawade Y. R. 4.
1Associate professor in Biochemistry, Department of Biochemistry, ESI Post Graduate Institute of Medical Sciences and Research, Andheri east, Mumbai , Maharashtra, India. 2Associate professor in Biochemistry, Government Medical College, Jagdalpur, Chhattisgarh, India. 3Assistant Professor in Biochemistry, Government Medical College, Nagpur, Maharashtra, India. 4Assistant Professor in Biochemistry and clinical nutrition Seth G S Medical College & KEM Hospital, Parel, Mumbai, Maharashtra, India.
Abstract:- Calcium and magnesium exert a major role upon diverse physiological process. Defect in calcium homeostasis have been seen in the asthma process. Antagonism of calcium and magnesium in the asthma and the beneficial effect of magnesium therapy in asthma have also been found in many studies. Children being the major target of asthma, we studied the blood levels of ionized calcium, total calcium, magnesium, sodium and potassium in 50 asthmatic children attending the pediatric OPD and compared with similar number of age and sex matched control. It was found that there was significant decrease in the levels of serum ionized calcium (1.15 ± 0.01 mmol/L), total calcium (8.93 ± 0.96mg/dl) and serum magnesium (1.91 ± 0.23 mg/dl)in asthmatic children as compare to the normal controls (1.24 ± 0.01 mmol/L), (9.35 ± 0.90 mg/dl) and (2.05 ± 0.23 mg/dl) respectively. The significant decrease was irrespective with the age, gender of patients and the severity of disease. In study group serum sodium (138 ± 3.4 mmol/L) and potassium (4.13 ± 0.46 mmol/L) showed no significant difference as compared to normal control group (139 ± 3.4 mmol/L) and (4.2 ± 0.53 mmol/L) respectively. A defect in calcium homeostasis may lead to increased utilization and translocation i.e. higher influx of calcium ions in bronchial smooth muscle cells and variety of other cells for e.g. mast cells which might have caused its lowering in plasma, ionized calcium being a physically active fraction which account for nearly half of the total calcium levels. These results suggest that airway hyper-responsiveness may be associated with altered calcium mobilization in airway smooth muscles. Utilization of magnesium for antagonism of calcium in the asthma process might have caused significant lowering in serum magnesium levels in asthmatic children as compare to normal controls. Key words:- asthma, hyper-reactivity, ionized calcium, magnesium. |
Filename | Nagdeote A. N. et. al..pdf |
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Created On: | 11/16/2011 00:00 |
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Last updated on | 12/17/2011 08:17 |
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