Property | Value |
Name | Synthesis, Characterization and Biological Evaluation of 4-Thiazolidinone Derivatives |
Description | Research article:-* Murugesan Sugumaran, Srinivasan Sethuvani, Marimuthu Poornima. Department of Pharmaceutical Chemistry, Adhiparasakthi College of Pharmacy, Melmaruvathur, Tamil nadu-603 319.India.
Abstract:- The 4-thiazolidinones is an important biological scaffold. A series of 4- thiazolidinone derivatives were synthesized from 4-amino benzoic acid. The synthesized compounds were confirmed by IR, 1H-NMR, Mass spectral data. The two synthesized compounds SS5 & SS6 were screened for anti-inflammatory and analgesic activity. Anti-inflammatory activity was evaluated by carrageenan-induced paw edema test and analgesic activity by Eddy’s hot plate method. Both the compounds showed good activity. All the experimental results were statistically significant. The anti-inflammatory and analgesic activity confirmed that the test compound SS6 showed superior activity than SS5. However, the test compounds were found to be less active than the standard drugs used.
Keywords:- Schiff bases; 4-thiazolidinone; Anti-inflammatory; Analgesic activity. |
Filename | Sugumaran Murugesan et al.pdf |
Filesize | 129.1 kB |
Filetype | pdf (Mime Type: application/pdf) |
Creator | admin |
Created On: | 03/17/2012 00:00 |
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Maintained by | Editor |
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Last updated on | 04/12/2012 18:08 |
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