Property | Value |
Name | The Antidiabetic Activity Of Combine Aqueous Extracts Of Gongronema latifolium (Benth) and Allium cepa. |
Description | Research article:- *1Obi HI, 1Ilodigwe EE, 1Ajaghaku DE, 2Okonta JM. 1Department of Pharmacology and Toxicology, Nnamdi Azikiwe University, Agulu campus, Anambra state, Nigeria. 2Department of Clinical Pharmacy, Nnamdi Azikiwe University, Agulu Campus, Anambra state, Nigeria. Abstract:- The antidiabetic efficacy of combined aqueous extract of Gongronema latifolium and Allium cepa a popular polyherbal therapy in treatment of diabetes mellitus in South Eastern Nigeria was assessed. Alloxan induced diabetic rats were used for the study. Surviving diabetic rats were divided into treatment and control groups. Treatment groups received the combined extracts (1:1, 1:2 and 2:1) orally at three different doses (100, 200 and 400mg/kg). Control groups received Glibenclamide (5mg/kg, oral) and normal saline. After oral administration of the combined extracts/drug, invivo measurement of blood glucose was taken hourly for 6 hours. Thereafter, oral administration was continued for 28days and blood glucose measurement was taken every 7 days. Single dose treatment and 28days treatment caused blood glucose reduction over the intervals monitored with different doses and ratios of the combined extracts. Increasing dosages of 1:1 and 2:1 of combined aqueous extracts produced a dose-dependent significant (p < 0.05) reductions in the blood glucose levels. These effects were comparable with antidiabetic effect of glibenclamide. This study showed that the combination of Gongronema latifolium and Allium cepa as a polyherbal antidiabetic remedy expressed good actions in reducing blood glucose when combined in the ratio of 1:1 or 2:1 than 1:2. b.
Keywords:- Polyherbal therapy, diabetes mellitus, alloxan, Gongronema latifolium, Allium cepa, blood glucose, positive synergy, hypoglycemic effect. |
Filename | Obi H I et al..pdf |
Filesize | 333.9 kB |
Filetype | pdf (Mime Type: application/pdf) |
Creator | admin |
Created On: | 06/17/2012 00:00 |
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Maintained by | Editor |
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Last updated on | 06/21/2012 05:37 |
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