Property | Value |
Name | Synthesis and Characterization of Tamarind-Polyvinyl Alcohol Blended with Cloisite 30B Nanocomposite for Controlled Release of the Ocular Drug Timolol maleate |
Description | Research article:- *Soumendra Sahoo1, Rashmirekha Sahoo2, Yogesh Panditrao Palve 3 and Padmalochan Nayak 3 1Melaka Manipal Medical College, Melaka, Malaysia. 2Nilai University , Nilai, Malaysia. 3P.L.Nayak Research Foundation and Center for Nanoscience and Nanotechnology, Synergy Institute and Technology, Bhubaneswar, Odisha, India.
Abstract:-In the present research program, polymer nanocomposites have been used as the drug carrier for delivery systems of ocular drugs. Tamarind and Polyvinyl Alcohol (PVA) with different ratios were blended with different wt% of Cloisite 30B solution by solvent casting method. Cloisite 30B was incorporated in the formulation as a matrix material component which also plays the role of a co-emulsifier in the nanocomposite preparation. Timolol maleate in different concentrations was loaded with Tamarind-PVA/C 30B nanocomposites for studying the in-vitro drug delivery systems. Morphology and structure characterization of nanocomposites were investigated by fourier transmission infra red spectroscopy (FTIR), scanning electron microscope (SEM), tensile strength and water uptake capacity. The drug release was studied by changing time, pH and drug concentrations. The kinetics of the drug release was studied in order to ascertain the type of release mechanism. Based on the diffusion as well as the kinetics, the mechanism of the drug release from the composite matrix has been reported.
Keywords:-Tamarind, PVA, C 30B, Timolol maleate, Ocular film, Drug Delivery. |
Filename | Soumendra Sahoo et al..pdf |
Filesize | 530.6 kB |
Filetype | pdf (Mime Type: application/pdf) |
Creator | admin |
Created On: | 09/04/2012 00:00 |
Viewers | Everybody |
Maintained by | Editor |
Hits | 9028 Hits |
Last updated on | 09/14/2012 03:42 |
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