Property | Value |
Name | The effect of Atorvastatin alone and in combination with Netilmicin in rheumatoid arthritis model in wistar rats |
Description | Research article:-Pharmacology Rajeev Kumar, Vasudevan Prabhakaran and Manoj G.Tyagi* Department of Pharmacology Christian Medical College, Vellore 632002,Tamilnadu,India.
Abstract:- Rheumatoid arthritis (RA) is a chronic inflammatory disease which mainly affects synovial joints and leads to damage of articular cartilage and ankylosis of joints. In this study, the effect of atorvastatin, an inhibitor of 3 hydroxyl -3-methyl glutaryl coenzyme reductase alone and in combination with netilmicin a phospholipase C inhibitor on RA were studied. RA was induced with the help of Freund ’s adjuvant (0.3ml/200gms wistar rat) in three separate Wistar rat groups. Freund ’s adjuvant is the combination of mineral oil, an emulsifier mannide monooleate with 1mg/ml heat killed dry mycobacterium tuberculosis H37Ra. During these studies, plethysmography, TNF-α levels, weight and age of animals were analyzed. After arthritis induction in group 1 (6 rats) the animals were treated with 5 mg/kg of Atorvastatin injection i.p and it was found to reduce 32.41 % of RA in 8 days as determined by paw edema and a reduction in TNF- α levels. While 42.22% reduction was found after 8 days treatment with the combination of 10 mg/kg of Netilmicin and Atorvastatin i.p injection in case of group 2 (6 rats) there was also a concomitant reduction in the levels of TNF-α in the arthritic paw. These studies suggest the interaction of these two drugs in reducing arthritic inflammation.
Key Words:- Freund’s adjuvant, atorvastatin, netilmicin, plethysmograph, arthritis, TNF-α. |
Filename | Tyagi G Manoj ,Prabhakaran V and Kumar Rajeev.pdf |
Filesize | 191.69 kB |
Filetype | pdf (Mime Type: application/pdf) |
Creator | admin |
Created On: | 10/05/2012 00:00 |
Viewers | Everybody |
Maintained by | Editor |
Hits | 4576 Hits |
Last updated on | 10/12/2012 17:24 |
Homepage | |
CRC Checksum | |
MD5 Checksum |