Property | Value |
Name | Therapeutic role of Nimodipine in acute ischemic stroke |
Description | Original article Aslam Mohd.a, Maurya Shesh Prakash b*, Khan Shadab Ahmed c, Habib Anwar d, Das Ashimae,Mehrotra Ginni f
Affiliation:- a,b,e SHKM Government Medical College, Mewat, Haryana, India c,dJawahar Lal Nehru Medical College, Aligarh, India fInstitute of IBSBT, CSJM University, Kanpur, India.
Author’s contributions- Aslam Mohd contributes towards concept, design, literature search, clinical studies, data acquisition, statistical analysis, manuscript writing and editing. Maurya Shesh Prakash helps in literature search, data analysis, manuscript editing, and writing. Khan Shadab Ahmed and Habib Anwar contribute towards data analysis and manuscript review. Das Ashima & Mehrotra Ginni analysed, collected the data and helped in manuscript writing.
Abstract: Background and objectives: Stroke is a worldwide health problem and contributes significantly to morbidity and mortality. Currently prevention of stroke is the best treatment. Once a stroke has occurred, then major goal in the treatment of acute ischemic stroke is to minimize the irreversible brain damage. One strategy of preserving neuronal function is to increase cerebral blood flow. Use of calcium antagonists during the “open therapeutic window” may result in neuronal function improvement. This study endeavours to establish therapeutic role of Nimodipine in acute ischemic stroke. Material and methods: The study was carried out in 75 patients of acute Ischemic stroke over a period of 1 year. Patients were randomly allocated to receive either nimodipine (120 mg/day) orally within 24 hrs of stroke onset or only best medical care consisting of antithrombotics. Neurological deficit was assessed using modified Mathew scale at admission and then on 3rd and 7th day. The patients comprised of two groups with score of either >65 or ≤65. Results: Total numbers of patients with score ≤65 were 39 out of which 20 patients received nimodipine. There was no significant improvement on giving nimodipine on the 3rd day of admission (P>0.05), but there was significant improvement on the 7th day ((P<0.05). Total number of patients with base line score of >65 were 36 out of which 20 patients received nimodipine. There was no significant improvement either on the 3rd (P>0.05) or 7th (P>0.05) day. Conclusion: These results suggest that patients of acute ischaemic stroke would benefit from nimodipine if started as early as possible.
Keywords:Calcium channel antagonists, Ischemic stroke, Modified Mathew scale, Nimodipine.
Article citation:- Aslam Mohd. et al. Therapeutic role of Nimodipine in acute ischemic stroke. Journal of pharmaceutical and biomedical sciences (J Pharm Biomed Sci.) 2013 August; 33(33): 1577-1581 .Available at http://www.jpbms.info
Copyright © 2013 Aslam Mohd. et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
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